Registration Dossier
Registration Dossier
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EC number: 203-026-2 | CAS number: 102-36-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented and scientifically acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- Backs of 2 male and 2 female rabbits were shaved. Compound was applied undiluted to the skin at a dose level of 2000 mg/kg. The test area was loosely covered with plastic. After 24 hours, wrappings were removed and test areas cleaned. Animals were observed 14 days for symptoms and mortality
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,4-dichlorophenyl isocyanate
- EC Number:
- 203-026-2
- EC Name:
- 3,4-dichlorophenyl isocyanate
- Cas Number:
- 102-36-3
- Molecular formula:
- C7H3Cl2NO
- IUPAC Name:
- 1,2-dichloro-4-isocyanatobenzene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- no death occured
- Clinical signs:
- other: no symptoms occured
- Gross pathology:
- at the time of sacrifice, a gross necropsy revealed a darkened ring at the base of the cortex of the kidneys, grainy texture of the liver, and lungs with edema and small hemorrhagic areas.
Any other information on results incl. tables
The dermal toxicity for male and female rabbits was greated than 2000 milligram per kilogram. No symptoms or death occurred over a 14 -day observation period. At the time of sacrifice, a gross necropsy revealed a darkened ring at the base of the cortex of the kidneys, grainy texture of the liver, and lungs with edema and small hemorrhagic areas. Other internal organs appeared normal.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Executive summary:
Backs of 2 male and 2 female rabbits were shaved. Compound was applied undiluted to the skin at a dose level of 2000 mg/kg. The test area was loosely covered with plastic. After 24 hours, wrappings were removed and test areas cleaned. Animals were observed 14 days for symptoms and mortality. LD50 > 2000 mg/kg bw.
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