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EC number: 235-697-2 | CAS number: 12542-30-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
- Principles of method if other than guideline:
- The study was conducted following a protocol based on BASF-internal standards.
- GLP compliance:
- no
Test material
- Reference substance name:
- Hexahydro-4,7-methano-1H-indenyl acrylate
- EC Number:
- 235-697-2
- EC Name:
- Hexahydro-4,7-methano-1H-indenyl acrylate
- Cas Number:
- 12542-30-2
- Molecular formula:
- C13 H16 O2
- IUPAC Name:
- 2-Propenoic acid hexahydro-4,7-methano-1H-indenyl ester
- Details on test material:
- - Name of the test substance used in the study report: Dihydrodicyclopentadienylacrylat
- Analytical purity: 99%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler / Henning
- Sex: female/male
- Age at study initiation: no data
- Mean body weight at study initiation: female 3.06 kg; male: 3.3 kg
- Diet (ad libitum): Ssniff K, standard diet for rabbits, INTERMAST GmbH, Soest
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
no details given
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin areas of the same animals
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): approx. 1 mL - Duration of treatment / exposure:
- 1 min, 5 min, 15 min, and 20 h
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: flank and back, 2.5 x 2.5 cm
- Type of wrap if used: the test patch which was wetted with the test substance was applied to the dorsal skin of the rabbits by means of a gummed linen patch that was fastened by an adhesive dressing.
REMOVAL OF TEST SUBSTANCE
- Washing: yes, with lutrol or lutrol:water (1:1) in case of 1, 5, and 15 min application; no washing in case of 20 h application
- Time after start of exposure: after 1, 5, and 15 min
SCORING SYSTEM: Draize Scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- (20 h exposure)
- Time point:
- other: 24-48 hours
- Score:
- 3.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- (20 h exposure)
- Time point:
- other: 24 - 48 hours
- Score:
- 3.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- (20 h exposure)
- Time point:
- other: 24 - 48 hours
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- (20 h exposure)
- Time point:
- other: 24 - 48 hours
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- (1, 5, 15 min exposure)
- Time point:
- other: 24 - 48 hours
- Score:
- 2.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- (1, 5, 15 min exposure)
- Time point:
- other: 24 - 48 hours
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- (1, 5, 15 min exposure)
- Time point:
- other: 24 - 48 hours
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- (1, 5, 15 min exposure)
- Time point:
- other: 24 - 48 hours
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
Any other information on results incl. tables
Mean erythema score after 24 and 48 h:
Exposure time |
Concentration [%] |
24 h |
48 h |
mean |
|||
|
|
Animal 1 |
Animal 2 |
Animal 1 |
Animal 2 |
Animal 1 |
Animal 2 |
1 min |
100 |
3** |
3** |
2* |
3** |
2.5 |
3.0 |
5 min |
100 |
3** |
3** |
2* |
3** |
2.5 |
3.0 |
15 min |
100 |
3** |
3** |
2* |
3** |
2.5 |
3.0 |
20 h |
100 |
4* |
3** |
3* |
4** |
3.5 |
3.5 |
* extending beyond the area of application
** extending far beyond the area of application
Mean edema score after 24 and 48 h:
Exposure time |
Concentration [%] |
24 h |
48 h |
mean |
|||
|
|
Animal 1 |
Animal 2 |
Animal 1 |
Animal 2 |
Animal 1 |
Animal 2 |
1 min |
100 |
3** |
3** |
3* |
3** |
3.0 |
3.0 |
5 min |
100 |
3** |
3** |
3* |
3** |
3.0 |
3.0 |
15 min |
100 |
3** |
3** |
3* |
2** |
3.0 |
2.5 |
20 h |
100 |
3* |
3** |
3* |
3** |
3.0 |
3.0 |
* extending beyond the area of application
** extending far beyond the area of application
Findings at test termination:
Exposure time |
Concentration [%] |
Skin findings |
|
|
|
Animal 1 |
Animal 2 |
1 min |
100 |
desquamation |
desquamation |
5 min |
100 |
desquamation |
desquamation |
15 min |
100 |
desquamation |
desquamation |
20 h |
100 |
desquamation |
desquamation* |
* extending beyond the area of application
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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