Registration Dossier
Registration Dossier
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EC number: 207-330-6 | CAS number: 462-95-3
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Low potential of bioaccumulation as log Kow <3.
Data related to metabolism of methylal (Dahl & Hadley, 1983; Tomilina et al., 1984; Poon et al., 2000; Virtue, 1951; Heilman J. & Duggan A., 2014), general metabolism of acetals (EFSA, 2011) and metabolism of degradation products (UNEP Publications, 2004) are provided in this section. Aim is to support the similarity of toxicokinetic behaviour between source and target of the read-across approach (Redebel, 2016).
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
ABSORPTION
Oral / gastrointestinal absorption
With a low molecular weight (104.15 g/mol), high water solubility (70 g/L) and log Kow of 0.84, oral/gastrointestinal absorption of ethylal is favoured subsequent to oral ingestion. Log Kow values between -1 and 4 are favourable for absorption by passive diffusion.
Oral absorption of ethylal is set to 100% for risk assessment.
Inhalation absorption
Ethylal high vapour pressure (17 kPa) indicates that the substance may be available for inhalation as a vapour. Its moderate log Kow value is favourable for absorption directly across the respiratory tract epithelium by passive diffusion. High solubility of ethylal in water indicates that it may be retained within the mucus.
Inhalation absorption of ethylal is set to 100% for risk assessment.
Dermal absorption
As a liquid with a molecular weight close to 100 g/mol, ethylal dermal uptake is favoured.
Based on molecular weight < 500 and log Kow in the (-1, 4) range, default dermal absorption of ethylal is set to 100% for risk assessment.
Dermal absorption of ethylal is set to 100% for risk assessment.
DISTRIBUTION
A wide distribution is expected due to the low molecular weight. As a small water-soluble molecule, ethylal is going to diffuse through aqueous channels and pores.
METABOLISM and EXCRETION
Ethylal is not considered as substance with a potential to accumulate within the body. The liver is known to be the greatest capacity for metabolism and the 2-week inhalation study shows slight but significant increases in liver weights of male and female rats exposed to 3000 ppm of ethylal without histopathological changes (Katz, 1987).
The following values for absorption assessment were taken into account according to ethylal behaviour (absorption, metabolism, distribution and elimination):
oral absorption of ethylal is set to 100% for risk assessment;
inhalation absorption of ethylal is set to 100% for risk assessment;
dermal absorption of ethylal is set to 100% for risk assessment.
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