Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Not applicable
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-amino-2-methylpropanol
EC Number:
204-709-8
EC Name:
2-amino-2-methylpropanol
Cas Number:
124-68-5
Molecular formula:
C4H11NO
IUPAC Name:
2-amino-2-methylpropan-1-ol
Details on test material:
- Name of test material (as cited in study report): AMP; P-1826
- Lot/batch No.: C450511

Test animals

Species:
mouse
Strain:
not specified
Sex:
female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
460, 300, 220, 180, 160 mg/kg
No. of animals per sex per dose:
Ten
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
230 mg/kg bw
Remarks on result:
other: ±25

Any other information on results incl. tables

Not applicable

Applicant's summary and conclusion

Conclusions:
The i.p. LD50 for female mice was 230±25 mg/kg.