Registration Dossier

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
July - December 1992
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
no
GLP compliance:
yes
Remarks:
This study has been performed in compliance with GLP in Switzerland, Procedures and Pronciples, March 1986, issued by the Swiss federal Department of the Interior and the Intercantonal Office for the Control of Medicaments.
Analytical monitoring:
yes
Vehicle:
no
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
155 mg CaCO3/l.
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: 95% CL: none
Duration:
72 h
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: 95% CL: none
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: 95% CL: none
Duration:
24 h
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: 95% CL: none
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Duration:
96 h
Dose descriptor:
LC0
Effect conc.:
100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality

Mortalities (Initial number of fishes = 10/test conc.)

 

Conc.

nominal

mg/l

Mortalities

Number of dead fish

 

24 h

48 h

72 h

96 h

Blank

0

0

0

0

10

0

0

0

0

18

0

0

0

0

32

0

0

0

0

58

0

0

0

0

100

0

0

0

0

 

Symptoms observed   

Conc.

nominal

mg/l

Swimming behaviour

Loss of equilibrium

Respiratory function

Exophtalmus

Pigmentation

 

24

48

72

96

24

48

72

96

24

48

72

96

24

48

72

96

24

48

72

96 h

Blank

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

10

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

18

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

32

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

58

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

100

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

 0 = no symptoms

Validity criteria fulfilled:
yes
Remarks:
Criteria: mortality in blank < 10%, constant conditions throughout the test, dissolved oxygen concentration > 60 % of the air saturation value, stable concentration of test substance throughout the test
Conclusions:
LC50,96h calculated: > 100 mg/l
NOEC96h: 100 mg/l
LC0,96h: 100 mg/l
LC100,96h: > 100 mg/l
Executive summary:

This study was performed in order to determine the acute toxicity of CA 1139 A to Rainbow Trout (Oncorhynchus mykiss).

The test was conducted according the OECD guideline 203.

10 fishes per concentration and control were used. Each aquarium was occupied by 5 fishes.

The nominal test concentrations were: 10, 18, 32, 58 and 100 mg test substance/l.

Mortalities were recorded after 24, 48, 72 and 96h exposure.

The fishes were examined daily for the symptoms.

The observed results were as follows:

LC50,96h calculated: > 100 mg/l

NOEC96h: 100 mg/l

LC0,96h: 100 mg/l

LC100,96h: > 100 mg/l

Values are based on nominal concentrations.

Description of key information

This study was performed in order to determine the acute toxicity of CA 1139 A to Rainbow Trout

(Oncorhynchus mykiss).
The test was conducted according the OECD guideline 203.
10 fishes per concentration and control were used. Each aquarium was occupied by 5 fishes.
The nominal test concentrations were: 10, 18, 32, 58 and 100 mg test substance/l.
Mortalities were recorded after 24, 48, 72 and 96h exposure.
The fishes were examined daily for the symptoms.
The observed results were as follows:
LC50,96h calculated: > 100 mg/l
NOEC96h: 100 mg/l
LC0,96h: 100 mg/l
LC100,96h: > 100 mg/l
Values are based on nominal concentrations.

Key value for chemical safety assessment

Additional information

 

 

Guideline Test Type

Species

Conclusion

 Reference

Reliability

 

OECD 203

Oncorhynchus mykiss

 LC50(96 h) > 100 mg/l

NOEC (96 h): 100 mg/l

LC0(96 h): 100 mg/l

Grade R., Ciba-Geigy, 1992

Reliable without restrictions