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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species, other
Type of information:
other: Weight-of-evidence based on experimental and QSAR data.
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Reason / purpose for cross-reference:
reference to other study
Reason / purpose for cross-reference:
reference to other study
Reason / purpose for cross-reference:
reference to other study
Principles of method if other than guideline:
QSAR calculation: see attached QMRF and QPRF in the section "Attached justification"
Experimental data: similar to OECD 107 TG
GLP compliance:
no
Remarks:
Weight-of-evidence based on a reliable experimental partition coefficient study and QSAR calculations falling into the applicability domain.
Key result
Type:
BCF
Value:
82.4 L/kg
Remarks on result:
other: Weight-of-evidence of a low potential of bioaccumulation supported by experimental and QSAR data on partition coefficient, and QSAR data on bioaccumulation
Conclusions:
Low potential of bioaccumulation
Executive summary:

Weight-of-evidence of a low potential of bioaccumulation supported by experimental and QSAR data on partition coefficient, and QSAR data on bioaccumulation.

Description of key information

No further investigation on the bioaccumulation are required.


1,3 diphenyl-2-thiourea has a low bioaccumulation potential.

Key value for chemical safety assessment

BCF (aquatic species):
82.4

Additional information

1,3-diphenyl-2-thiourea is expected to have a low potential of bioaccumulation.


The Weight-of-Evidence approach is supported by:


- a reliable experimental data on partition coefficient (log Kow=2);


- A QSAR calculation of the partition coefficient falling into the applicability domain of the model (log Kow=3.6) and


- a QSAR calculation of the BCF falling into the applicability domain of the model (BCF=82.4L/kg)