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Diss Factsheets
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EC number: 217-101-2 | CAS number: 1739-84-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- The effect of Histamine H2 Receptor Antagonist on Platelet Aggregation in Man
- Author:
- Horton MA, Amos RJ and Jones JJ
- Year:
- 1 983
- Bibliographic source:
- Scand J Haematol (1983) 31, 15-19
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The in vitro effects on platelet aggregation of various imidazole (cimetidine, oxmetidine, burinamide. metiamide) and non-imidazole (ranitidine) histamine H2 receptor antagonists and structural analogues of imadazole. Platelet aggregation was studied using and ADG Intruments aggregometer. Effects were measured in vitro by preincubation of platelet rich plasma with 20 µl or test substance for 1 minute.
- GLP compliance:
- no
- Type of method:
- in vitro
- Endpoint addressed:
- other: Platelet aggregation
Test material
- Reference substance name:
- 1,2-dimethylimidazole
- EC Number:
- 217-101-2
- EC Name:
- 1,2-dimethylimidazole
- Cas Number:
- 1739-84-0
- Molecular formula:
- C5H8N2
- IUPAC Name:
- 1,2-dimethyl-1H-imidazole
- Details on test material:
- - Name of test substance (as cited in study report): 1,2-Dimethylimidazol
Constituent 1
Test animals
- Details on test animals or test system and environmental conditions:
- Platelet rich plasma (PRP) was obtained form citrated blood (1:9, citrate 3.8 %: whole blood) from 6 normal male volunteers using standard methods; all had been drug free for at least 14 days. Aggregation was induced in 200 µl of PRP by the addition of 20 µl ADP at final concentrations of 20, 10, 5, 2, 1 and 0.4 µmol/l un 5 and 20 µl of collagen suspension.
Administration / exposure
- Details on study design:
- - Tested dose range: 30, 250, 500, 1000 µmol/l
Results and discussion
- Details on results:
- The test substance showed up to the highest tested concentration of 1000 µmol/l no reduction in the aggregation rate in comparison to control.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.