Registration Dossier
Registration Dossier
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EC number: 617-745-8 | CAS number: 856976-65-3
Endpoint summary
Administrative data
Description of key information
The related test substance Bis-2,4-dimethylphenoxy-propan-1,3-ol-2 (read across) was neither skin nor eye irritating.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation
In a skin irritation test to white vienna rabbits a study was conducted with the test substance Bis-2,4-dimethylphenoxy-propan-1,3-ol-2 (read across) according to OECD guideline 404. 2 males and 1 female were exposed for 4 hours to the test substance and observed for 72 hours. The rabbits got an application of 0.5 mL of the undiluted and heated test substance to the test patch (2.5 cm x 2.5 cm). The mean erythema of animal 1 was 0.7, of animal two 0.3, same value for animal 3. The erythema effect was fully reversible within 48 h. The edema score was 0 for all animals. In conclusion to these results the test item showed no irritating effects.
Eye irration
In an eye irritation test to white vienna rabbits a study was conducted with the test substance Bis-2,4-dimethylphenoxy-propan-1,3-ol-2 (read across) according to OECD guideline 405. 2 males and 1 female were exposed to 0.1 mL of unchanged test substance after heating at about 40 °C. The study was conducted with a single application to the conjunctival sac of the right eyelid. The substance was not washed out. The cornea and the iris score showed a score of 0 for all animals. The conjunctivae score was 0.7 for animal 1 and 0.3 for animal 3. Animal 2 showed no effects. After 72 h of observation the test substance showed no irritating effects.
Justification for selection of skin irritation / corrosion endpoint:
Only key study available
Justification for selection of eye irritation endpoint:
Only key study available
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is not considered to be classified under Directive 67/548/EEC, as amended for the 31st time in Directive 2009/2/EG.
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. As a result the substance is not considered to be classified under Regulation (EC) No 1272/2008, as amended for the sixth time in Regulation No 605/2014.
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