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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
No information
Author:
HSDB
Year:
2003
Bibliographic source:
HSDB (Hazardous Substances Data Bank), a database of the National Library of Medicine's TOXNET system

Materials and methods

Test guideline
Guideline:
other: no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Coumarin
EC Number:
202-086-7
EC Name:
Coumarin
Cas Number:
91-64-5
Molecular formula:
C9H6O2
IUPAC Name:
2H-chromen-2-one

Test animals

Species:
rat
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
293 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Substance is harmful under DSD and toxic under CLP
To be classified as Xn;R20/21/22 or Acute toxicity category 3; H301 (oral)/H311 (dermal)/H331 (inhalation)