Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

Endpoint:
developmental toxicity
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Title:
No information
Author:
IARC
Year:
2000
Bibliographic source:
IARC volume 77-9 (2000), monograph on coumarin

Materials and methods

Test guideline
Guideline:
other: no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Coumarin
EC Number:
202-086-7
EC Name:
Coumarin
Cas Number:
91-64-5
Molecular formula:
C9H6O2
IUPAC Name:
2H-chromen-2-one

Test animals

Species:
other: rats, rabbits and miniature pigs

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Key result
Dose descriptor:
NOEC
Effect level:
> 100 other: fold the human therapeutic dose plus rutin
Based on:
test mat.
Basis for effect level:
clinical signs

Results (fetuses)

Effect levels (fetuses)

Key result
Dose descriptor:
NOEC
Effect level:
> 100 other: fold the human therapeutic dose plus rutin
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: no effects were seen

Fetal abnormalities

Key result
Abnormalities:
not specified

Overall developmental toxicity

Key result
Developmental effects observed:
not specified

Applicant's summary and conclusion