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Diss Factsheets
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EC number: 210-856-9 | CAS number: 624-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP non-guideline, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 955
- Report date:
- 1955
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Method: Before OECD Guideline 404 was established in 1982, skin irritation was tested using an internal method (BASF test). White Vienna rabbits were used. Usually, 2 animals were treated for 1, 5 and 15 minutes and 2 other animals for 20 hours using occlusive conditions. An application site of 2.5 X 2.5 cm was covered with the liquid or powdered and moistened test substance. After the application time, the skin was washed with water which sometimes contained a mild detergent (e.g. Lutrol (50%)). The animals were observed 7 to 8 days and skin changes were recorded on working days. The report usually describes findings after 24 hours and at the end of the observation period.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-chloropropyne
- EC Number:
- 210-856-9
- EC Name:
- 3-chloropropyne
- Cas Number:
- 624-65-7
- Molecular formula:
- C3H3Cl
- IUPAC Name:
- 3-chloroprop-1-yne
- Details on test material:
- - Name of test material (as cited in study report): Propargylchlorid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: alcohol
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Experiment 1, concentration: 0.1, 0.5, 1, 10, 20, 50, 100 %
- Experiment 2, concentration: 100 %
VEHICLE
- Experiment 1, concentration: 90% - Duration of treatment / exposure:
- - Experiment 1 (0.1, 0.5, 1, 10, 20, 50, 100 % test material): 20 hours
- Experiment 2 (100% test material): 1, 5, 15, or 60 minutes - Observation period:
- 6 weeks
- Number of animals:
- - Experiment 1: 2 (0.1, 0.5, 1, 10, 100 %) or 4 (20, 50 %)
- Experiment 2: 2 per time point - Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm (patch test)
- Type of wrap if used: bandage
REMOVAL OF TEST SUBSTANCE
- After the application time, the skin was washed
Results and discussion
In vivo
- Irritant / corrosive response data:
- More than 1 animal had necrosis:
- Experiment 1: necrosis observed in 2 out of 4 animals, in the 20 and 50 % group
- Experiment 2: necrosis observed in 2 out of 2 animals, in the 60 min group
Edema was observed in all animals exposed to 50 % and 100% of the test material.
Any other information on results incl. tables
Results after 20 hours exposure (Experiment 1)
Concentration (100%) |
Effects |
100 |
Redness, oedema, crusts, scaling |
50 |
Redness, oedema, crusts, scaling, necrosis, scarring |
20 |
Redness, crusts, scaling, necrosis, scarring |
10 |
Slight redness, scaling |
1 |
Slight redness |
0.5 |
No irritation |
0.1 |
Slight redness |
Results after exposure with pure test material (Experiment 2)
Exposure duration |
|||
1 min |
5 min |
15 min |
60 min |
Redness, oedema, crusts, scaling, necrosis, subcutaneous haemorrhage |
Redness, oedema, crusts, scaling, necrosis, scarring, subcutaneous haemorrhage |
Redness, oedema, crusts, scaling, necrosis, scarring, subcutaneous haemorrhage |
Redness, oedema, crusts, necrosis, subcutaneous haemorrhage |
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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