Registration Dossier
Registration Dossier
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EC number: 805-721-1 | CAS number: 57625-74-8
Carcinogenicity
Administrative data
Description of key information
The substance was predicted to be "non-carcinogen" by all QSAR model of VegaNIC v.1.1.1 .
Key value for chemical safety assessment
Carcinogenicity: via oral route
Link to relevant study records
- Endpoint:
- carcinogenicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The prediction was performed by a valid QSAR model and appears to be reliable as the substance is included in the applicability domain of the model.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Guideline:
- other: REACH guidance on QSARs R6, May 2008
- Principles of method if other than guideline:
- General model for estimating the carcinogenicity.
- Details on results:
- Assessment of the prediction:
the prediction is considered as reliable based on the following issues:
- predicted substance is into the Applicability Domain of the model
- strongly similar compounds with known experimental value in the training set have been found
- similar molecules found in the training set have experimental values that agree with the predicted value
- accuracy of prediction for similar molecules found in the training set is good
- all atom centered fragment of the compound have been found in the compounds of the training set
- model class assignment is well defined
- predicted value agrees with experimental values of training set compounds laying in the same neuron
- descriptors for this compound have values inside the descriptor range of the compounds of the training set
Details are provided in attachment on the section: "attached full study report". - Relevance of carcinogenic effects / potential:
- The substance is predicted to be non-Carcinogen.
- Conclusions:
- According to this prediction, the substance is not carcinogenic.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available (further information necessary)
Justification for classification or non-classification
According to Directive 67/548/EEC and to Regulation (EC) n. 1272/2008, the substance is not classified for carcinogenicity because the available data are inconclusive.
Additional information
Data predicted by carcinogenicity models (CAESAR and Benigni-Bossa) indicate that the substance is non-carcinogen.
Overall, no experimental data are available.
Justification for selection of carcinogenicity via oral route endpoint:
Only data by QSAR model are available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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