Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 805-721-1 | CAS number: 57625-74-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Link to relevant study records
- Endpoint:
- genetic toxicity in vitro
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The prediction was performed by a valid QSAR model and appears to be reliable as the substance is included in the applicability domain of the model.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Guideline:
- other: REACH guidance on QSARs R6, May 2008
- Principles of method if other than guideline:
- General model for estimating the mutagenicity.
- Genotoxicity:
- negative
- Additional information on results:
- Model assessment:
the prediction is considered as reliable considering the following issues:
- predicted substance is into the Applicability Domain of the model
- strongly similar compounds with known experimental value in the training set have been found
- similar molecules found in the training set have experimental values that agree with the predicted value
- accuracy of prediction for similar molecules found in the training set is good
- all atom centered fragment of the compound have been found in the compounds of the training set
- descriptors for this compound have values inside the descriptor range of the compounds of the training set
Details are provided in attachment on the section: "attached full study report". - Conclusions:
- Interpretation of results (migrated information):
negative
According to this prediction, the substance should not have genotoxic activity.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available (further information necessary)
Additional information
Data predicted by mutagenicity models of of VegaNIC v.1.1.1 (CAESAR, SarPy and Benigni-Bossa) indicate that the substance is non-mutagen.
Overall, no experimental data are available.
Justification for selection of genetic toxicity endpoint
Only data by QSAR model are available.
Justification for classification or non-classification
According to Directive 67/548/EEC and to Regulation (EC) n. 1272/2008, the substance is not classified for mutagenicity because the available data are inconclusive.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
