Registration Dossier
Registration Dossier
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EC number: 209-708-6 | CAS number: 591-22-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
3,5-Lutidine was tested in female BALB/c mice in a local lymph node assay (LLNA) and found to be weakly sensitizing, with a SI of 5 after topical exposure of 50% in vehicle. However, this substance was found not to be irritating in a preliminary screening assay measuring mouse ear swelling after topical exposure. The weak response and the absence of irritation lead to questioning the validity of the findings.
Migrated from Short description of key information:
Weakly sensitizing, stimulation index (SI) = 5 at highest dose tested.
Justification for selection of skin sensitisation endpoint:
Experimental result
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
- Migrated from Short description of key information:
no study available
Justification for classification or non-classification
3,5-Lutidine was tested in BALB/c mice in a LLNA and found to be weakly positive, with a SI of 5, at the highest dose tested (50% in vehicle). There is strong evidence that the substance is corrosive or strongly irritating in specific assays for skin irritation and acute dermal toxicity. However, in the LLNA, the substance was found to be nonirritating when in the acetone/olive oil vehicle, in the screening assay performed prior to LLNA dosing. There is anecdotal evidence from immunotoxicologists in contract research organizations that chemicals which cause dermal irritation can result in false positive findings in the LLNA. Considering that, in general, pyridine and methyl pyridines are not sensitisers, the accuracy of this one test finding is questioned and the substance is not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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