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EC number: 433-360-6 | CAS number: 34036-80-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-02-23 to 1999-03-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to EEC method B3 and OECD guidleline 402 with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 433-360-6
- EC Name:
- -
- Cas Number:
- 34036-80-1
- Molecular formula:
- C18H29N3O3Si
- IUPAC Name:
- 6-{[(butan-2-ylidene)amino]oxy}-3,9-dimethyl-6-phenyl-5,7-dioxa-4,8-diaza-6-silaundeca-3,8-diene
- Reference substance name:
- 2-butanone-O,O',O''- (phenylsilylidyne)trioxime
- IUPAC Name:
- 2-butanone-O,O',O''- (phenylsilylidyne)trioxime
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): OS-9000
- Physical state: Clear liquid
- Analytical purity: >92%
- Lot/batch No.: M-350B
- Expiration date of the lot/batch: 12 February 2000
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Spague Dawley CD obtained fiom Harlan U.K. Ltd., Bicester, Oxon, England.
- Age at study initiation: eight to eleven weeks
- Weight at study initiation: 219 to 242 g
- Fasting period before study:
- Housing: Individually in stainless steel metal cages (20cm high x 39cm wide x 39cm long) until Day 3 when they were returned to group housing.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 18-22 ºC
- Humidity: 28- 52 %
- Photoperiod: time switch to provide 12 hours of artificial light (0700 - 1900 hours) in each 24-hour period.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Dorso lumbar region, equivalent approximately to 10% of the total body weight.
- % coverage: Treatment area (50mm x 50mm) was covered with porous gauze with a non-irritating dressing
- Type of wrap if used: Further covered by a waterproof dressing encircled firmly around the trunk of the animal.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Washed with warm water (38ºC) and blotted dry with absorbent paper.
- Time after start of exposure: 24 hours
TEST MATERIAL:
- Amount(s) applied (volume or weight with unit): 1.947 mL/kg bw
- Concentration (if solution): Administered as supplied. - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 rats per sex and per dose.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed soon after dosing and at frequent intervals for the remainder of Day 1. On subsequent days animals were observed on at least two occasions during the day. Bodyweight of each rat was recorded on days 1 (prior to dosing), 8 and 15.
- Necropsy of survivors performed: Yes
- Other examinations performed: clinical signs, dermal responses (using the scoring system according to the guidelines), body weight, macroscopic pathology (opening the thoracic and abdominal cavities)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no deaths throughout the study.
- Clinical signs:
- other: There was no evidence of a systemic response in any animal throughout the study.
- Gross pathology:
- No macroscopic abnormalities were observed for animals killed at study termination.
- Other findings:
- Dermal responses: No treatment related dermal reactions were seen in any animal during the study.
Any other information on results incl. tables
The acute lethal dermal dose to rats was demonstrated to be greater than 2000 mgkg bodyweight.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute lethal dermal dose to rats was demonstrated to be greater than 2000 mg/kg bodyweight.
- Executive summary:
The study was designed to assess the toxicity of the test item following a single dermal administration to the rat according to EEC method B3 and OECD guideline 402. Five rats per sex rats were exposed by topical application (dorso lumbar region) to 2000 mg/kg bw under occlusive conditions. After 24 hours of exposure the treated area was washed with water. No treatment related dermal reactions were seen in any animal during the study. No deaths and no evidence of a systemic response in any animal throughout the study. The acute lethal dermal dose to rats was demonstrated to be greater than 2000 mg/kg bodyweight.
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