2(1H)-Pyridinone, 1-(acetyloxy)-

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

15 May 2013 to 17 March 2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Conducted according to current test guidelines and GLP compliant

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2014

Report date:

2014

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 170

Deviations:

no

GLP compliance:

yes

Type of method:

determination of fibre length and diameter distributions

Type of distribution:

mass based distribution

Test material

Test material information

Constituent 1

Reference substance name:

2-oxo-1,2-dihydropyridin-1-yl acetate

EC Number:

689-986-7

Cas Number:

1742-79-6

Molecular formula:

C7H7NO3

IUPAC Name:

2-oxo-1,2-dihydropyridin-1-yl acetate

Constituent 2

Reference substance name:

1742-78-6

IUPAC Name:

1742-78-6

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

Name: Oxypyrion acetate
CAS Number: 1742-78-6
Batch number: 14058400
Purity: 97.83%
Date of arrival: 22 April 2013
Expiry date: 30 November 2013
Storage conditions: Refrigerated (2 to 8°C)

Results and discussion

Particle size

Particle size 1

Percentile:

D50

Mean:

ca. 363 µm

Remarks on result:

other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.

Particle size 2

Percentile:

D10

Mean:

< 75

Remarks on result:

other: As 11.89% of the test sample passed through the smallest 75 µm sieve, a more precise value for D10 is not possible from the results data.

Particle size 3

Percentile:

D50

Mean:

363 µm

Remarks on result:

other: Not applicable

Particle size 4

Percentile:

D90

Mean:

1 271 µm

Remarks on result:

other: Not applicable

Any other information on results incl. tables

The quantity of Oxypyrion acetate for this was determined to be 81,6 g using the tap density determined in this report. The sample weight used for the test was 82,40 g.

The range was given by the size of the sieve where the sum of residue, R_x,was = 90 % and the size of the sieve where the sum of residue, R_x,was = 10 %. However, the calculated R_xvalue for the largest sieve (2000 µm) was 12,25% and the calculated R_xvalue for the smallest sieve (75 µm) was 85,67% therefore the granule size range is <75 µm to >2000 µm.

A plot was made of percentage cumulative residue against granule size and from this the values of D10 (the maximum granule size below which 10% of the sample weight exists), D50 (the maximum granule size below which 50% of the sample weight exists – also known as the median particle size by weight) and D90 (the maximum granule size below which 90% of the sample weight exists).

The results calculated from the plot were:

D10 <75 µm – as 11.89% of the test sample passed through the smallest, 75µm, sieve a more precise value for D10 is not possible from the results data.

D50 = 363 µm

D90 = 1271 µm

Applicant's summary and conclusion

Conclusions:

The granule size range for Oxypyrionacetate was <0,75 µm to >2000 µm.