Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 692-448-4 | CAS number: 170621-28-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 May - 14 Jun 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- National Institute for Quality- and Organizational Development in Healthcare and Medicines, National Institute of Pharmacy, Budapest, Hungary
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- divanadium(5+) dialuminium(3+) magnesium(2+) nonaoxidandiide
- EC Number:
- 692-448-4
- Cas Number:
- 170621-28-0
- Molecular formula:
- Mg2xAl2xVyOz
- IUPAC Name:
- divanadium(5+) dialuminium(3+) magnesium(2+) nonaoxidandiide
- Test material form:
- solid: particulate/powder
- Details on test material:
- light yellow
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CRL (WI) BR of Wistar origin
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Toxi-Coop Zrt., Budapest, Hungary
- Age at study initiation: 8-12 weeks
- Weight at study initiation: 229-239 g (males) and 184-188 g (females)
- Housing: animals were individually housed in Type II polycarbonate cages with certified laboratory wood bedding (Lignocel® Hygienic Animal Bedding, J. Rettenmaier & Söhne GmbH+Co. KG, Rosenberg, Germany).
- Diet: ssniff® SM R/M-Z+H complete diet (ssniff Spezialdiäten GmbH, Soest, Germany), ad libitum
- Water: drinking water, ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 30-70
- Air changes (per hr): 8-12
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 30 May 2012 To: 14 June 2012
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- >= 2.3 - <= 2.7 µm
- Geometric standard deviation (GSD):
- >= 3.05 - <= 3.29
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: anodised aluminium Flow Past Exposure Chamber (CR Equipment SA, Switzerland)
- Exposure chamber volume: 2.8 L
- Method of holding animals in test chamber: animals were held in polycarbonate restraining tubes
- Source and rate of air: filtered air at 15.9 L/min (0.99 L/min to each animal port)
- Method of conditioning air: the air was supplied by an oil-free air compressor and was filtered in a two-stage filter set. The temperature of the air was regulated by a heat exchanger.
- System of generating particulates/aerosols: dust aerosol generator type Wright (TSE Systems GmbH, Bad Homburg, Germany)
- Method of particle size determination: cascade impactor (IN-TOX Products, NM, USA)
- Temperature, humidity: 23.0-26.2 °C, 8.9-24.6%
TEST ATMOSPHERE
- Brief description of analytical method used: the atmosphere generated was measured gravimetrically at regular intervals (approx. 50 min) during exposure by pulling a volume of 5 L of test atmosphere from the exposure chamber through glass fibre filters (Fiberfilm T60A20, Pallflex Product Corp.). The duration of each sampling was 5 minutes. Sampling was performed 5 times: shortly after chamber equilibration and then at regular intervals during the exposure. Samples were collected from a vacant animal exposure port (animals' breathing zone). The actual sampling schedule employed was designed in order to obtain adequate quantities of test item. The achieved average concentration was calculated by combination of the gravimetric results and the recorded real-time data provided by the Aerosol Light Scattering Photometer integrated in the monitoring system of the exposure apparatus. The photometer was calibrated during the technical trials and the recorded data were corrected following the treatment according to the results of gravimetric concentration measurements. The test atmosphere concentration measurements were conducted also during sighting exposure.
- Samples taken from breathing zone: yes
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: see Table 1 under “Any other information on materials and methods incl. tables")
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): 2.5 µm/3.18 µm (main study); 3.4 μm/2.76 µm (sighting study) - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetric and photometric (aerosol light scattering photometer)
- Duration of exposure:
- 4 h
- Concentrations:
- SIGHTING STUDY:
- 5 mg/L (target concentration)
- 5.8 mg/L (analytical concentration)
MAIN STUDY:
- 5 mg/mL (target concentration)
- 4.852 mg/mL (analytical concentration)
- 16.3 mg/L (nominal concentration) - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were observed for clinical signs at the first, second and third hour during exposure, as soon as practicable following removal from restraint, 1 hour after exposure and subsequently once daily during the 14-day observation period. Individual bodyweights were recorded prior to exposure (Day 0) and on Days 1, 3, 7 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
- Preliminary study:
- A preliminary sighting exposure was performed at a target concentration of 5 mg/L (analytical concentration: 5.8 mg/L) in 1 male and 1 female rat for a period of 4 h. All animals survived the treatment and the following 96 h.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 4.852 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortalities occurred during the whole study period.
- Clinical signs:
- other: No clinical signs of toxicity were noted up to the end of the 14-day observation period.
- Body weight:
- In both genders, body weight loss (-1.6% in males and -2.6% in females) was observed on the day of inhalation exposure. A compensation of body weight loss in males and females was found from Day 3 of the observation period.
- Gross pathology:
- No macroscopic findings were observed at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- CLP: not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.