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EC number: 692-448-4 | CAS number: 170621-28-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 Dec 2019 - 12 Feb 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- adopted 13 Apr 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- adopted 31 May 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: samples were analysed on day 0 and 5
- Sample storage conditions before analysis: Samples were stored for 5 days at 50°C - Buffers:
- - pH: 4, 7, 9
- Composition of buffer:
pH 4 (160 mL CH3COOH, 2 M + 80 mL CH3COONa, 1 M + ad. 2000 mL water p.a.)
pH 7 (17.4173 g KH2PO4 + 1000 mL water + 29.8 mL NaOH, 2M + ad. 2000 mL water p.a.)
ph 9 (6.1864 g H3BO3 + 7.4582 g KCL + 1000 mL water p.a. + 21.5 mL NaOH, 2M + ad 2000 mL water p.a.)
During the repetition of the tier 1 in pH 9 buffer, the buffer was prepared as follows: 6.1860 g H3BO3 + 7.4582 g KCL + 1000 mL water p.a. + 21.5 mL NaOH, 2M + ad 2000 mL water p.a. - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: 60 mL PP flasks
- Sterilisation method: solutions were membrane filtrated via sterile 0.45 µm nylon filters andadditionally filtrated via 0.2 µm nylon filters
- Lighting: no
TEST MEDIUM
- Volume used/treatment: 5 g test item with 100 mL water p.a.
- Preparation of test medium: The dissolution of aluminium magnesium vanadium oxide was done similar to OECD 105 enhanced method for synthetic amorphous silica SAS. The saturated test item solutions were further diluted in order to achieve the condition < 0.01 M as laid down in OECD 111. Due to higher solubility of the test item in pH 4 and 7 buffer solutions, the pH 4 solutions were 10 fold diluted, pH 7 solution 4f old and pH 9 solutions 2 fold diluted in order to achieve the concentration < 0.01 M or half saturated concentration. The test item solutions with the concentration 50 g/L were separately prepared in pH 4, 7 and 9 buffer solutions and were shaken for 70.5 h at room temperature.
OTHER TEST CONDITIONS
- Adjustment of pH: yes - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 50 g/L
- Remarks:
- 10 fold diluted
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 50 g/L
- Remarks:
- 4 fold diluted
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 50 g/L
- Remarks:
- 2 fold diluted
- Number of replicates:
- 2
- Positive controls:
- no
- Negative controls:
- no
- Statistical methods:
- Concentrations were determined using linear calibration function. Stability in % at time t was calculated dividing the concentration of Al/Mg/V after 5 d storage by the concentration of AI/MG/V at the beginning of tier 1.
- Transformation products:
- no
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Details on results:
- TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: Yes
Reference
Summary Al
pH nominal |
Dilution factor |
0 h |
5 d |
Stability [%] |
||
Conc. Al [mg/L] |
RSD [%] |
Conc. Al [mg/L] |
RSD [%] |
|||
pH 4 |
10 |
< 0.05 |
- |
< 0.05 |
- |
- |
pH 7 |
4 |
1.743 |
3.2 |
1.853 |
2.1 |
106.3 |
pH 9 |
2 |
50.57 |
3.4 |
41.06 |
4.9 |
81.2 |
Summary Mg
pH nominal |
Dilution factor |
0 h |
5 d |
Stability [%] |
||
Conc. Mg [mg/L] |
RSD [%] |
Conc. Mg [mg/L] |
RSD [%] |
|||
pH 4 |
10 |
123.8 |
1.2 |
122.1 |
1.2 |
98.6 |
pH 7 |
4 |
< 2.0 |
- |
< 2.0 |
- |
- |
pH 9 |
2 |
< 2.0 |
- |
< 2.0 |
- |
- |
Summary V
pH nominal |
Dilution factor |
0 h |
5 d |
Stability [%] |
||
Conc. Mg [mg/L] |
RSD [%] |
Conc. Mg [mg/L] |
RSD [%] |
|||
pH 4 |
10 |
< 0.03 |
- |
< 0.03 |
- |
- |
pH 7 |
4 |
65.12 |
0.3 |
65.97 |
3.3 |
101.3 |
pH 9 |
2 |
0.601 |
2.7 |
0.616 |
0.8 |
102.5 |
Description of key information
The amounts of Al (pH 7) / Mg / V after five days was more than 90% of the amount at the start of the test, therefore Aluminium magnesium vanadium was considered to be stable.
Key value for chemical safety assessment
Additional information
The hydrolysis and stability of the dissolved test item Aluminium magnesium vanadium oxide in dependence of the pH was determined by measurement of Aluminium (Al), Magnesium (Mg) and Vanadium (V) concentrations in filtrated test solutions with the nominal concentration 50 g/L (10 fold diluted pH 4 buffer solution, 4 fold diluted pH 7 buffer solution and 2 fold diluted pH 9 buffer solutions). As more than 90% of Mg and V was found after
the storage of solutions for 5 days at 50 °C, the whole test item was considered to be stable, and no further examination was made.
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