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Diss Factsheets
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EC number: 213-107-4 | CAS number: 924-50-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: EG Guideline B.4 Akute Toxizität Hautreizung der Richtlinie 84/449/EWG
- Qualifier:
- according to guideline
- Guideline:
- other: Richtline 83/467/EWG
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-Methylcrotonsäuremethylester
- IUPAC Name:
- 3-Methylcrotonsäuremethylester
- Reference substance name:
- Methyl 3-methyl-2-butenoate
- EC Number:
- 213-107-4
- EC Name:
- Methyl 3-methyl-2-butenoate
- Cas Number:
- 924-50-5
- Molecular formula:
- C6H10O2
- IUPAC Name:
- methyl 3-methylbut-2-enoate
- Test material form:
- other: clear liquid
- Details on test material:
- Purity: 97.3 %, storage: 22°C dark under the hood,
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- BW: 2,1-2,8 kg, Age: 3-5 months, single housing, room temperatur: 20 +/-3 °C, Humidity: 50+/- 20%, Light/dark: 12/12h , Feeding: Altromin 2123 Haltungsdiet Kaninchen, Altromin GmbH, Lage/Lippe, ad libitum and hay (15 g daily), chlorinated water (ad libitum), Source: Hoechst AG, Kastengrund, fully air conditioned, single housing, ID: ear marked,
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3 animals per group
- Details on study design:
- The animals were shaved (with an electronic shaver; 25 m2 dorsal of the hull) 24 hours before the experiment was accomplished.Only animals with
an intact skin were used. Every animal was patched with a plaster and a 2.5x2.5 cm cellulose. Under the plaster 0.5 ml of the substance (not diluted) was administered and ligated with a semiocclusive bandage. The exposure time was 4 h . After exposure the substance was removed with lukewarm water. The examination followed after 30-60 minutes, 24h, 48 h and 72 h, 7, 14 and 21 days after the plaster was removed.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24h, 48h, 72h
- Score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24h, 48h, 72h
- Score:
- 0
- Other effects:
- One animals showed dry skin.
Any other information on results incl. tables
See: (attached background material)
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test item is not irritating to the skin.
- Executive summary:
30 min and 48h after the plaster was removed erythema were diagnosed (in all animals) . One animal had a clear visible erythema after 72 h plus a dry and rough skin. After 7 days all irritation symptoms were reversible.Only one animal showed a dry and rough skin surface after 7 days.
It can be concluded that the test item is not irritating to the skin.
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