Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-265-7 | CAS number: 80-26-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Alpha-Terpinyl Acetate is considered to be not irritating to the skin when using CLP criteria. It is not irritating to eye and is not expected to be a respiratory irritant either.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study is performed in compliance with OECD guideline 404 but reliability 2 is assigned because observations were not followed until the reversibility of the effects (only 7 days)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- The skin observations should have been extended after 7 days because they were not fully reversible.
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- other: albino
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume with unit): 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 7 days
- Number of animals:
- Test 1: 3
Test 2&3: 4 - Details on study design:
- SCORING SYSTEM: Draize scoring system
- tested in a multi-patch study - Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- other: 24, 48 and 72 h
- Score:
- 1.89
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 1
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- other: 24, 48 and 72 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 1
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- other: 24, 48 and 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 2
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- other: 24, 48 and 72 h
- Score:
- 2.33
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 2
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- other: 24, 48 and 72 h
- Score:
- 1.75
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 3
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- other: 24, 48 and 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 3
- Irritant / corrosive response data:
- Test 1: One animal showed marked desquamation at the 7 day time interval. The other two animal showed desquamation at the 7 day time interval.
Test 2:One animal showed desquamation at the 7 day time interval. One other animal showed slight desquamation at the 7 day time interval.
Test 3: One animal showed minimal desquamation at the 7 day time interval. The other three other animals showed slight desquamation at the 7 day time interval. - Interpretation of results:
- other: not irritating using CLP criteria
- Remarks:
- Criteria used for interpretation of results: other: the substance is irritating using DSD criteria
- Conclusions:
- For substances CLP is leading and therefore the substance is considered to be not irritating.
- Executive summary:
In three primary dermal irritation studies performed according to OECD guideline 404 and in compliance with GLP, three or four albino rabbits were dermally exposed to 0.5 mL of undiluted alpha-Terpinyl Acetate under a semi-occlusive patch for 4 hours to intact skin of the flank. Animals were then observed for 7 days. Irritation was scored by the method of Draize at 1, 24, 48 and 72 hours and 7 days after exposure. Mean individual scores at 24, 48 and 72 h after exposure for the 3 animals of the first test were 1.66, 2 and 2 for erythema score and 1, 2 and 2 for edema score. For the second test 2, 2, 2 and 2 for erythema score and 3, 2, 2 and 2 for edema score. For the third test the mean individual scores were 2, 1.67, 2 and 1,33 for erythema score and 2, 1, 0.67 and 0.33 for edema score. Under the test conditions the substance is considered to be irritating to the skin.
Reference
Test 1
|
1 hr |
1 day |
2 days |
3 days |
7 days |
Mean (24, 48, 72 hrs) |
Animal No. 1 |
||||||
Erythema |
0 |
1 |
2 |
2 |
1 |
1.67 |
Oedema |
0 |
1 |
1 |
1 |
1 |
1 |
Animal No. 2 |
|
|||||
Erythema |
2 |
2 |
2 |
2 |
1 |
2 |
Oedema |
1 |
2 |
2 |
2 |
1 |
2 |
Animal No. 3 |
|
|||||
Erythema |
1 |
2 |
2 |
2 |
2 |
2 |
Oedema |
2 |
2 |
2 |
2 |
1 |
2 |
Test 2
|
1 hr |
1 day |
2 days |
3 days |
7 days |
Mean (24, 48, 72 hrs) |
Animal No. 1 |
||||||
Erythema |
2 |
2 |
2 |
2 |
2 |
2 |
Oedema |
3 |
3 |
3 |
3 |
1 |
3 |
Animal No. 2 |
|
|||||
Erythema |
2 |
2 |
2 |
2 |
1 |
2 |
Oedema |
2 |
2 |
2 |
2 |
1 |
2 |
Animal No. 3 |
|
|||||
Erythema |
2 |
2 |
2 |
2 |
1 |
2 |
Oedema |
2 |
2 |
2 |
2 |
1 |
2 |
Animal No. 4 |
|
|||||
Erythema |
1 |
2 |
2 |
2 |
1 |
2 |
Oedema |
0 |
2 |
2 |
2 |
1 |
2 |
Test 3
|
1 hr |
1 day |
2 days |
3 days |
7 days |
Mean (24, 48, 72 hrs) |
Animal No. 1 |
||||||
Erythema |
2 |
2 |
2 |
2 |
1 |
2 |
Oedema |
1 |
2 |
2 |
2 |
1 |
2 |
Animal No. 2 |
|
|||||
Erythema |
1 |
2 |
2 |
1 |
1 |
1.67 |
Oedema |
1 |
2 |
1 |
0 |
0 |
1 |
Animal No. 3 |
|
|||||
Erythema |
1 |
2 |
2 |
2 |
1 |
2 |
Oedema |
1 |
1 |
1 |
0 |
0 |
0.67 |
Animal No. 4 |
|
|||||
Erythema |
1 |
2 |
1 |
1 |
0 |
1.33 |
Oedema |
0 |
1 |
0 |
0 |
0 |
0.33 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 August 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as unpublished report, no restrictions, fully adequate for assessment.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- TNO Triskelion, Utrechtseweg 48, Zeist, the Netherlands
- Species:
- other: ROSS, spring chicken eyes
- Details on test animals or tissues and environmental conditions:
- Approximately 7 weeks old, male or female chickens (ROSS, spring chickens), body weight range approximately 1.5 - 2.5 kg, were used as eye-donors. Heads of these animals were obtained from poultry slaughterhouse v. Miert, Breukelen, the Netherlands. Heads of the animals were cut off immediately after sedation of the animals by electric shock and incision of the neck for bleeding, and before they reached the next station on the process line. The heads were placed in small plastic boxes on a bedding of paper tissues moistened with isotonic saline. Next, they were transported to the testing facility. During transportation, the heads were kept at ambient temperature.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Control eyes
- Amount / concentration applied:
- 30 µL
- Duration of treatment / exposure:
- 10 seconds
- Observation period (in vivo):
- The eyes were examined at approximately 0, 30, 75, 120, 180 and 240 minutes after treatment.
- Number of animals or in vitro replicates:
- Three test eyes per test sample, one negative control eye and three positive control eyes were selected for testing.
- Details on study design:
- Within 2 hours after kill, eyes were carefully dissected and placed in a superfusion apparatus using the following procedure: First the eye-lids were carefully removed without damaging the cornea and a small drop of Fluorescein sodium BP 2.0% w/v (Minims, Chauvin, England) was applied to the corneal surface for a few seconds and subsequently rinsed off with isotonic saline at ambient temperature. Next, the head with the fluorescein-treated cornea was examined with a slit-lamp microscope (Slit-lamp 900 BP, Haag-Streit AG, Liebefeld-Bern, Switzerland) to ensure that the cornea was not damaged. lf undamaged (e.g., fluorescein retention and corneal opacity scores of ≤ 0.5), the eye was further dissected from the head without damaging the eye or cornea. Care was taken to remove the eye-ball from the orbit without cutting off the optical nerve too short. The enucleated eye was placed in a stainless steel clamp with the cornea positioned vertically and transferred to a chamber of the superfusion apparatus (TNO, Zeist, the Netherlands). The clamp holding the eye was positioned in such a way that the entire cornea was supplied with isotonic saline from a bent, stainless steel tube, at a target rate of 0.10 - 0.15 mL/min (peristaltic pump set at speed 5.00, Watson-Marlow 205C4, Rotterdam, the Netherlands). The chambers of the superfusion apparatus as well as the saline were temperature controlled at approximately 32°C (water pump set at 36.4°C; Lauda 103, Germany). After placing in the superfusion apparatus, the eyes were examined again with the slit-lamp microscope to ensure that they were not damaged. Corneal thickness was measured using the Depth Measuring Attachment No. I for the Haag-streit slit-lamp microscope. Corneal thickness was expressed in instrument units. An accurate measurement was taken at the corneal apex of each eye. Eyes with a corneal thickness deviating more than 10% of the average corneal thickness of the eyes, eyes showing opacity (score higher than 0.5), or were unacceptably stained with fluorescein (score higher than 0.5) indicating the cornea to be permeable, or eyes that showed any other signs of damage, were rejected as test eyes and replaced. Three test eyes per test sample, one negative control eye and three positive control eyes were selected for testing. Each eye provided its own baseline values for corneal swelling, corneal opacity and fluorescein retention. For that purpose, after an equilibration period of 45-60 minutes, the corneal thickness of the eyes was measured again to determine the zero reference value for corneal swelling calculations. The isolated chicken eyes were exposed to a single application of 30 uL of the test sample for 10 seconds followed by a 20 mL saline rinse. After rinsing, each eye in the holder was returned to its chamber. The eyes were examined at approximately 0, 30, 75, 120, 180 and 240 minutes after treatment. Fluorescein retention was only scored at approximately 30 minutes after treatment. All examinations were carried out with the slit-lamp microscope. After the final examination, the test substance treated eyes, the negative and positive control eyes were preserved in a neutral aqueous phosphate-buffered 4% solution of formaldehyde. The corneas were embedded in paraffin wax, sectioned at 5 µM and stained with PAS (Periodic Acid-Schiff). The microscopic slides were filed in the archives and kept available for histopathological examination if considered relevant. ln the case of Terpinyl Acetate Alpha, histopathological examination was considered not relevant, because no borderline severe corneal effects were observed.
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 30 min
- Score:
- 0.5
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 75 min
- Score:
- 1
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 120, 180, 240 min
- Score:
- 1.2
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 30 min
- Score:
- 1
- Max. score:
- 100
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 75, 120 , 180 min
- Score:
- 4
- Max. score:
- 100
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 240
- Score:
- 3
- Max. score:
- 100
- Irritation parameter:
- other: Fluorescein retention
- Basis:
- mean
- Time point:
- other: 30 min
- Score:
- 0.7
- Max. score:
- 3
- Irritant / corrosive response data:
- Terpinyl Acetate Alpha caused very slight corneal swelling, slight or slight to moderate corneal opacity, and very slight or slight fluorescein retention. The calculated lrritation lndex was 42 (max possible score is 200). The negative control eye did not show any corneal effect and demonstrated that the general conditions during the tests were adequate. The positive control eyes showed severe corneal effects and demonstrated the suitability and sensitivity of the ICE to detect severe eye irritants.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to the UN-GHS and the EU-CLP classification schemes of the lCE, Terpinyl Acetate Alpha is considered to be "Not Classified".
- Executive summary:
In a GLP compliant isolated chicken eye test performed according to OECD guideline 438, the eye irritation potential of Terpinyl Acetate Alpha was evaluated. Isolated chicken eyes were exposed to a single application of 30 uL of the test sample for 10 seconds followed by a 20 mL saline rinse. Three main parameters were measured to disclose possible adverse eye effects: corneal thickness (expressed as corneal swelling), corneal opacity and fluorescein retention of damaged epithelial cells. Terpinyl Acetate Alpha caused very slight swelling of the cornea, slight or slight to moderate corneal opacity, and very slight or slight fluorescein retention. The calculated lrritation lndex was 42 (max possible score is 200). The negative control (saline) caused no corneal effects. The positive control BAC 5% caused moderate corneal swelling, severe opacity and severe fluorescein retention. The calculated lrritation lndex was 42 (max possible score is 200). According to the UN-GHS and the EU-CLP classification schemes of the lCE, TerpinylAcetate Alpha is considered to be "Not Classified".
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
For alpha-Terpinyl Acetate, skin irritation information is available. Four in vivo skin irritation tests according to the OECD TG 404 have been performed. Three of these have been reported in ECETOC (1995) and one is performed by the Toxicol Lab. In ECETOC report, three primary dermal irritation tests are presented. These are performed according to OECD guideline 404 and in compliance with GLP, three (test 1) or four (test 2 and 3) albino rabbits were dermally exposed to 0.5 mL of undiluted alpha-Terpinyl Acetate under a semi-occlusive patch for 4 hours to intact skin of the flank (ECETOC 1995). Animals were then observed for 7 days. Irritation was scored by the method of Draize at 1, 24, 48 and 72 hours and 7 days after exposure. Mean individual scores at 24, 48 and 72 h after exposure for the 3 animals of the first test were 1.66, 2 and 2 for erythema score and 1, 2 and 2 for edema score. For the second test the mean individual scores were 2, 2, 2 and 2 for erythema score and 3, 2, 2 and 2 for edema score. For the third test the mean individual scores were 2, 1.67, 2 and 1,33 for erythema score and 2, 1, 0.67 and 0.33 for edema score. At the end of the observation period of 7 days, reversibility of the effects was seen but in some animals slight desquamation was visible.
In the skin irritation study by the Toxicol Lab four albino rabbits were dermally exposed to 0.5 mL of undiluted alpha-Terpinyl Acetate, under a semi-occlusive patch for 4 hours to the clipped skin of the trunk (Hayes 1986). Animals were then observed for 7 days. Erythema and oedema was scored at 1, 24, 48 and 72 hours and 7 days after exposure. The average (24 + 48 + 72 hours) erythema score was 1.8 and the average oedema score was 1.0. Seven days after dosing very slight reaction remained in three animals and desquamation from the surface of the treated skin was apparent in all four rabbits. In this study, alpha-Terpinyl Acetate was found not to be skin irritant when applied topically to the rabbit.
Eye irritation
In a GLP compliant isolated chicken eye test performed according to OECD guideline 438, the eye irritation potential of alpha-Terpinyl Acetate was evaluated (TNO Triskelion 2012). Isolated chicken eyes were exposed to a single application of 30 uL of the test sample for 10 seconds followed by a 20 ml saline rinse. Three main parameters were measured to disclose possible adverse eye effects: corneal thickness (expressed as corneal swelling), corneal opacity and fluorescein retention of damaged epithelial cells. Alpha-Terpinyl Acetate caused very slight swelling of the cornea, slight or slight to moderate corneal opacity, and very slight or slight fluorescein retention. The calculated lrritation lndex was 42 (max possible score is 200). The negative control (saline) caused no corneal effects. The positive control BAC 5% caused moderate corneal swelling, severe opacity and severe fluorescein retention. The calculated lrritation lndex was 42 (max possible score is 200). According to the UN-GHS and the EU-CLP classification schemes of the lCE, alpha-Terpinyl Acetate is considered to be "Not Classified".
Respiratory irritation
For respiratory irritation mostly human data are used for the assessment because no suitable in vitro or in vivo tests are available that can identify respiratory irritation (REACH guidance R.7.2.3). There are no human data such as indicated in R7.2.3 of the ECHA guidance that indicate respiratory reactions of the substance e. g. from consumer experience or occupational exposure. Despite the slight skin irritating potential, the substance is not corrosive or severely irritating which further minimizes the respiratory irritation hazard (REACH guidance: 7.2.1.2).
Justification for selection of skin irritation / corrosion endpoint:
Four skin irritation studies are available performed with alpha-Terpinyl Acetate. Though the substance need to be classified and labelled according to DSD. It is decided that for the risk characterisation the conclusion on CLP is leading because this is the classification scheme for substances under REACH.
Justification for selection of eye irritation endpoint:
One eye irritation study is available, which is performed in accordance with OECD 438 and GLP. This study is adequate for covering this endpoint.
Justification for classification or non-classification
The skin irritation results in all four tests are fairly consistent. The erythema and oedema scores are around 2. The effects are reversible but at the end of the observation period at day 7 slight erythema (circa 1) and some desquamation may be seen. The interpretation for classification and labelling are presented in the table below:
Test 1/3 animals |
Test 1 |
Test 2 |
Test 3 |
Test 4 |
Reference |
ECETOC |
ECETOC |
ECETOC |
Toxicol lab |
Erythema average |
< 2 (1.89) |
2 |
< 2 (1.75) |
< 2 (1.67) |
Oedema average |
< 2 (1.66) |
2.3 |
< 2 (1) |
< 2 (0.75) |
Number of animals erythema score >=2 |
2/3 |
4/4 |
2/4 |
2/4 |
Number of animals oedema score >=2 |
2/3 |
4/4 |
1/4 |
1/4 |
Erythema/Oedema and desquamation (de) at the end of the observation period |
1-2 + de |
Mostly 1+ and de |
1 + de |
0-1 + de |
DSD criteria |
Yes based on scores 2 or > in 2/3 animals |
Yes based on scores 2 in 4/4 animals |
No: based on scores lower than 2 and only 2 and 1 out of 4 animals showing the erythema or oedema, respectively |
No based on scores lower than 2 and only 2 and 1 out of 4 animals showing the erythema or oedema, respectively |
Number of animals erythema score >=2.3 |
0 |
0 |
0 |
0 |
Number of animals oedema score >=2.3 |
0 |
1 out of 4 showed oedema 3,1 showed oedema 2.3all others were 2 |
0/4 showed |
0 |
CLP criteria |
Not reached scores remain <2.3 and no animals having scores > 2. |
No only two out of 4 animals shows oedema score>2.3 |
No all scores are <2.3 |
No all scores are <2.3 |
The erythema score of ≥2, seen at 2/3 or 10/15 animals, result in the DSD classification and labelling. Since no animals scored erythema >=2.3 and only two animals oedema of >= 2.3, CLP labelling is not needed. The slight irritation effects seen at the end of the observation period of 7 days indicate reversibility and are therefore not considered for classification and labelling because it can be anticipated that these effects are fully reversible within 14 days. These effects and the desquamation seen at the end of the test do not indicate effects needed for classification.
The effects seen result in Xi:R38 according to the EU Directive 67/548 and absence of classification and labelling according to the EU Classification, Labelling and Packaging of Substances (CLP) Regulation (EC) No. 1272/2008.
The in vitro eye irritation study with alpha-Terpinyl Acetate showed minor eye irritation which does not warrant classification according to the EU Directive 67/548 for mixtures and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
The absence of skin and eye irritation potential shows that the substance is not corrosive or severely irritating which minimizes the respiratory hazard (REACH guidance: 7.2.1.2). Therefore, classification for respiratory irritation is not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.