Registration Dossier
Registration Dossier
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EC number: 202-000-8 | CAS number: 90-51-7
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment
Bioaccumulation study was conducted on test organism Cyprinus carpiofor 6 weeks for evaluating the bioconcentration factor (BCF value) of test chemical (authoritative databases, 2018).The study was performed according to other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances" under flow through conditions at a temperature of 25°C and pH range 6.0-8.5, respectively. Cyprinus carpio (length - 8 dimensionless) was used as a test organism for the study. Test chemical nominal conc. used for the study was 1 mg/land 0.1 mg/l, respectively. Range finding study involve theTLm(48h) 335 ppm (w/v) on Rice fish (Oryzias latipes).The bioconcentration factor (BCF value) of test chemical on Cyprinus carpio was determined to be in the range of 0.1-0.5 L/Kg at a conc. of 1 mg/l and 1-7.1 L/Kg at a conc. of 0.1 mg/l, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.
Additional information
Bioaccumulation: aquatic / sediment
Experimental study and various predicted data of the test chemical were reviewed for the bioaccumulation end point which are summarized as below:
In an experimental key study from authoritative databases (2018), bioaccumulation experiment was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of test chemical. The study was performed according to other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances" under flow through conditions at a temperature of 25°C and pH range 6.0-8.5, respectively. Cyprinus carpio (length - 8 dimensionless) was used as a test organism for the study. Test chemical nominal conc. used for the study was 1 mg/land 0.1 mg/l, respectively. Range finding study involve the TLm(48h) 335 ppm (w/v) on Rice fish (Oryzias latipes).The bioconcentration factor (BCF value) of test chemical on Cyprinus carpio was determined to be in the range of 0.1-0.5 L/Kg at a conc. of 1 mg/l and 1-7.1 L/Kg at a conc. of 0.1 mg/l, respectively.
In a prediction done using the BCFBAF Program of Estimation Programs Interface was used to predict the bioconcentration factor (BCF) of test chemical. The bioconcentration factor (BCF) of test chemical was estimated to be 3.162 L/kg whole body w.w (at 25 deg C).
In an another prediction done by using Bio-concentration Factor module (ACD (Advanced Chemistry Development)/I-Lab predictive module, 2017)), Bio-concentration Factor of the test chemical was estimated to be 1 dimensionless at pH range 1-14, respectively.
On the basis of above results for test chemical, it can be concluded that the BCF value of test chemical ranges from 0.1 to 7.1, respectively,which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.
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