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EC number: 202-112-7
CAS number: 91-97-4
A study was performed to assess the
mutagenicity potency of TODI. The method was similar to OECD Guideline
471 (Bacterial Reverse Mutation Assay and EU Method B.13/14
(Mutagenicity - Reverse Mutation Test Using Bacteria) of Commission
Directive 92/69/EEC (which constitues Annex V of Council Directive
67/548/EEC). The test strains S. typhimurium TA 1535, TA 1537, TA 1538,
TA 98, TA 100, TA 102, TA 104 and E. coli WP2 uvr A as well as E. coli
WP2 uvr A pKM 101 were examined at 10, 20, 50, 100, 200, 500, 1000, 2000
µg TODI/plate. Mutagenicity (frame-shift) was observed for S.
typhimurium TA 98 and TA 1538 at concentrations of 10 to 1000 µg/plate.
An evaluation of 2000 µg/plate was not possible due to growth
inhibition. The reported data of this mutagenicity assay according to
AMES shows, that after metabolic activation, the test item induced gene
mutations by frameshift in the genome of 2 of 9 (S. typhimurium TA 98
and TA 1538) strains used. Therefore, TODI is considered mutagenic in
this bacterial reverse mutation assay.
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