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EC number: 202-112-7
CAS number: 91-97-4
Although there is no respective study result
for TODI available, for precautionary reasons TODI was classified as a
substance that "may cause allergy or asthma symptoms or breathing
difficulties if inhaled" as (1) TODI was found as sensitizer in a
Magnusson & Kligman maximisation study in the guinea pig and (2) similar
substances as e.g. MDI (CAS no. 9016-87-9) and
4,4'-Methylendicyclohexyldiisocyanat (CAS no. 5124-30-1; EC no.
225-863-2) are also labelled with H317 and H334 due to the isocyanic
moiety as a common structural alert. Based on the available data
described for similar isocyanates, a potential for respiratory
sensitisation is likely for TODI too. Therefore the TODI is expected to
be a respiratory sensitiser.
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