Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
respiratory sensitisation, other
Remarks:
Expert Statement
Type of information:
other: Expert statement
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No study result but rational argumentation also considering structural analogue substances.
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
other: expert statement
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: expert evaluation
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3,3'-dimethylbiphenyl-4,4'-diyl diisocyanate
EC Number:
202-112-7
EC Name:
3,3'-dimethylbiphenyl-4,4'-diyl diisocyanate
Cas Number:
91-97-4
Molecular formula:
C16H12N2O2
IUPAC Name:
3,3'-dimethylbiphenyl-4,4'-diyl diisocyanate
Test material form:
solid

Test animals

Species:
other: not applicable
Strain:
other: not applicable
Details on test animals or test system and environmental conditions:
not applicable

Test system

Route of induction exposure:
other: not applicable
Route of challenge exposure:
other: not applicable
Vehicle:
other: not applicable
Concentration:
not applicable
No. of animals per dose:
not applicable
Details on study design:
not applicable
Challenge controls:
not applicable

Results and discussion

Results:
Although there is no respective study result for TODI available, for precautionary reasons TODI was classified as a substance that "may cause allergy or asthma symptoms or breathing difficulties if inhaled" as (1) TODI was found as sensitizer in a Magnusson & Kligman maximisation study in the guinea pig and (2) similar substances as e.g. MDI (CAS no. 9016-87-9) and 4,4'-Methylendicyclohexyldiisocyanat (CAS no. 5124-30-1; EC no. 225-863-2) are also labelled with H317 and H334.

Applicant's summary and conclusion

Interpretation of results:
sensitising
Conclusions:
Although there is no respective study result for TODI available, for precautionary reasons TODI was classified as a substance that "may cause allergy or asthma symptoms or breathing difficulties if inhaled" as (1) TODI was found as sensitizer in a Magnusson & Kligman maximisation study in the guinea pig and (2) similar substances as e.g. MDI (CAS no. 9016-87-9) and 4,4'-Methylendicyclohexyldiisocyanat (CAS no. 5124-30-1; EC no. 225-863-2) are also labelled with H317 and H334 due to the isocyanic moiety as a common structural alert. Based on the available data described for similar isocyanates, a potential for respiratory sensitisation is likely for TODI too. Therefore the TODI is expected to be a respiratory sensitiser.
Executive summary:

Although there is no respective study result for TODI available, for precautionary reasons TODI was classified as a substance that "may cause allergy or asthma symptoms or breathing difficulties if inhaled" as (1) TODI was found as sensitizer in a Magnusson & Kligman maximisation study in the guinea pig and (2) similar substances as e.g. MDI (CAS no. 9016-87-9) and 4,4'-Methylendicyclohexyldiisocyanat (CAS no. 5124-30-1; EC no. 225-863-2) are also labelled with H317 and H334 due to the isocyanic moiety as a common structural alert. Based on the available data described for similar isocyanates, a potential for respiratory sensitisation is likely for TODI too. Therefore the TODI is expected to be a respiratory sensitiser.