Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Endpoint summary

Administrative data

Description of key information

(1S,5R)-6,8-Dioxabicyclo[3.2.1]octan-4-one (Cyrene™) is a liquid at ambient temperature and pressure, with a measured freezing point of <-20°C and a measured boiling point of 227°C at 100.7 kPa. It has a measured relative density of 1.25 at 20°C and measured vapour pressure value of 28 Pa at 25°C. Cyrene™ has a measured surface tension value of 72.5 mN/m at 22°C for a nominal concentration of 1 g/L and viscosity values of 13.81 mPa.s at 20°C and 6.95 mPa.s at 40°C.

In the presence of water, Cyrene™ forms a reversible dynamic equilibrium with the geminal diol or Gem Diol [C(OH)2]. This is discussed further in the attached document in Section 13. At concentrations relevant for studies of aqueous physicochemical properties, the Gem Diol form predominates. Therefore, the measured water-based values are considered relevant for both form.

Cyrene™/Gem Diol has a water solubility of 52.6 to 90 w/w% at 20°C and pH 3.09 to 3.15 (determined by visual inspection), and a measured log Kow value of -1.52 at 22°C and pH 5.18 to 5.24.

Cyrene™ is not classified for flammability in accordance with Regulation (EC) No. 1272/2008 on the basis of a measured flash point of 108°C at 101.9 kPa and measured boiling point of 227°C at 100.7 kPa. It has a measured auto-ignition temperature of 296°C at 100.3 to 101.3 kPa and is not explosive and not oxidising on the basis of structural examination. Cyrene™ is determined to be non-hazardous as no gases were evolved in any of the four steps under the conditions of an EU Test Method A.12.

Additional information