Registration Dossier
Registration Dossier
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EC number: 239-183-9 | CAS number: 15123-80-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The skin sensitising potential was evaluated in a Local Lymph Node Assay (LLNA) following OECD 406 (Pénzes, 2011). Aluminium molybdenum oxide was tested in concentrations of 10%, 25%, and 50% in DMF based on the result of a range-finding test. 25% hexyl cinnamic aldehyde in acetone/olive oil (AOO) was used as positive control. The criteria used to consider a positive response, is a 3-fold increase of the stimulation index (SI) compared to the negative control. 4 CBA/Ca mice per group were topically treated with 25 µL of the appropriate formulations of the test item, the positive control substance and the vehicle using a pipette, on the dorsal surface of each ear. Each animal was dosed once a day on 3 consecutive days. There was no treatment on days 4, 5, and 6. On day 6, the animals were intravenously injected via the tail vein with 250 µL of sterile PBS containing 20 µCi of ³H-methyl-thymidine. After sacrifice, the draining auricular lymph nodes were excised, removed and pooled per group and a single cell suspension of lymph node cells was prepared. The incorporated radioactivity was measured and expressed as the amount of radioactive disintegration per minute (DPM) and transformed in DPN (DPN = DPM/number of pooled lymph nodes). The SI is the ratio of DPN of the treated mice and the negative control. The resuls for the SI values were 0.4, 0.4, and 0.9 for 10%, 25%, and 50%, respectively. The SI for the negative controls were 1.0 (DMF and AOO) and for the positive control 5.5. Therefore, aluminium molybdenum oxide is considered not skin sensitising based on the result of this LLNA.
Migrated from Short description of key information:
Skin Sensitisation:
Local Lymph Node Assay (OECD 406): not sensitising
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The available data on skin sensitisation of the test substance do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification.
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