Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-096-5 | CAS number: 26896-48-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 11 DEC 1980 to 2 JAN 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- ; occlusive wrapping, individual housing only during exposure
- Principles of method if other than guideline:
- The study is a pre-guideline study following the method of Noakes and Sanderson (Brit. J. Indust. Med. 1969, 26, 59-64). The method used is similar to OECD Guideline 402 (Acute Dermal Toxicity).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Tricyclodecanedimethanol
- EC Number:
- 248-096-5
- EC Name:
- Tricyclodecanedimethanol
- Cas Number:
- 26896-48-0
- Molecular formula:
- C12H20O2
- IUPAC Name:
- [3-(hydroxymethyl)tricyclo[5.2.1.0²,⁶]decan-8-yl]methanol
- Details on test material:
- - Name of test material (as cited in study report): TCD - Alkohol DM
- Physical state: viscous liquid
- Analytical purity: no data
- Stability under test conditions: no data
- Storage condition of test material: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Tuck and Sons Limited, Battlesbridge, Essex, England
- Age at study initiation: no data
- Weight at study initiation: 171 - 237 g
- Fasting period before study: yes
- Housing: individually during the 24 hour exposure period, and then in groups of up to 5 animals; solid floor polypropylene cages furnished with softwood sawdust
- Diet (e.g. ad libitum): rat diet, Nottingham University, Sutton Bonington, Leicestershire, England
- Water (e.g. ad libitum): yes
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 ± 3°C
- Humidity (%): no data
- Air changes (per hr): 20
- Photoperiod (hrs dark / hrs light): 10 /14
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 6 x 10 cm, dorsal and lateral
- % coverage: no data
- Type of wrap if used: aluminium foil thinly covered with test substance hold in place by encircling the trunk of the animal with a strip of elastic adhesive bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): sponging with detergent and warm water followed by rinsing with water and drying
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 10 mL/kg
- Concentration (if solution): pure test substance - Duration of exposure:
- 24 h
- Doses:
- 10000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation at 0.5, 1 and 4 hours following treatment and then once daily for 14 days, weighing at day 0 and day 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 10 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: None of the animals died during the 14 days observation period.
- Mortality:
- None of the treated animals (5 males and 5 females) died.
- Clinical signs:
- other: All animals exhibited subdued activity up to 4 hours after treatment.
- Gross pathology:
- No abnormal macroscopic lesions were observed in any of the test animals.
- Other findings:
- The dermal application caused no irritation and no changes were noted at the terminal examination at 14 days post application.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal toxicity was determined to be > 10000 mg/kg bw. Thus the acute dermal toxicity is very low. No classification is required according to EU legislation.
- Executive summary:
In an acute dermal toxicity study, 5 male and 5 female adult Sprague-Dawley rats were dermally exposed to octahydro-4,7 -methano-1H-indenedimethanol (TCD-Alkohol DM) for 24 hours at a single dose of 10000 mg/kg bw. The exposed area was about 6 x 10 cm. Animals were observed for 14 days.
No mortality was observed.
Thus the dermal LD50 is > 10000 mg/kg bw (LD0 = 10000 mg/kg bw; Collier/Safepharm, 1981a).
Octahydro-4,7 -methano-1H-indenedimethanol (TCD-Alkohol DM) is of low dermal toxicity based on the observed LD50 value.
This acute dermal toxicity study in the rat is acceptable. It complies with the OECD guideline 402
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.