Registration Dossier
Registration Dossier
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EC number: 248-096-5 | CAS number: 26896-48-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- year of publication: 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Reference substance 001
- Details on test material:
- 13 aliphatic alcohols, carbon chain lengths C1- C10
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- cf. chapter 7.5.3
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 6 - 7 h
- Remarks on duration:
- per day
- Concentrations:
- up to max. achievable vapor concentrations at chamber temperature 21-27°C
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The vapor pressure of long chain aliphatic alcohols with carbon chain lengths of C5 and more, including 1-nonanol, is too low to reach vapor concentrations that cause toxicity following single or repeated inhalation exposure (6 or 7 h/day, days 1-19 of gestation in combined repeated toxicity/reproduction toxicity study; cf. chapter 7.5.3).
It is concluded that this finding does also apply for TCD alcohol DM with its carbon structure of C12. The vapor pressure is determined to be < 1 hPa (extrapolated from experimental result; see Sect. 4.6) - Executive summary:
There was no inhalation toxicity seen in rats exposed to higher aliphatic alcohols. The vapor pressure of long chain aliphatic alcohols with carbon chain lengths of C5 and more, including 1 -octanol, 1-nonanol, and 1 -decanol, is too low to reach vapor concentrations that cause toxicity following single or repeated inhalation exposure (6 or 7 h/day, days 1-19 of gestation in a combined repeated toxicity/reproduction toxicity study; cf. chapter 7.5.3) (Nelson et al., 1990).
It is concluded that this finding does also apply for TCD alcohol DM with its carbon structure of C12.
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