Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 603-894-6 | CAS number: 135108-88-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The toxicity of Formaldehyde, polymer with benzenamine, hydrogenated to activated sludge microorganisms was determined in a GLP study according to EC method C.11 (2008). On the basis of the effective concentrations describing the respiration inhibition of activated sludge caused by the test substance, Formaldehyde, polymer with benzenamine, hydrogenated was found to have an EC50 (3 h) of 187 mg/l (95% confidence interval: 137 – 251 mg/l).
Key value for chemical safety assessment
- EC50 for microorganisms:
- 187 mg/L
Additional information
Test performance
Test was performed according to: Method C.11 - Activated Sludge Respiration Inhibition Test, Council Regulation (EC) No. 440/2008, published in O.J.L 142, 2008.
The preliminary test was performed using 5 concentrations in range 46 – 1 000 mg.L-1with a geometric factor of 2.2 to determinethe concentrations to be used in the main test.
In the main test, 5 concentrations of the test substance in geometric progression with factor of 2.0 (50, 100, 200, 400, 800 mg.L-1) were used together with two control experiments (without the test substance), one at the beginning and one at the end of the test.
3,5-dichlorophenol was used as reference substance. Five concentrations in geometric progression with a factor of 1.4 (5.2, 7.3, 10, 14 and 20 mg.L-1) were selected.
The abiotic decomposition was not detected even at the highest concentration of the test substance.
The pH value during the main test was in the range of 7.1 to 9.7.
Validity of test
The test met the following validity criteria:
- the respiration rates of two control experiments should not differ from each other by more than 15 %
- the EC50value of the reference substance should be in the range of 5 – 30 mg.L-1
The difference of two respiration
rates of control experiments at the beginning and the end
of the main test from each other was:
± 0.59 mg.L-1.h-1= ± 3.72 % (if the value of lower control 15.79 mg.L-1.h-1= 100 %)
The 3h-EC50value of reference substance, 3,5-dichlorophenol:
EC50= 8.1 mg.L-1(95% confidence interval: 7.6 – 8.6 mg.L-1)
Since all criteria for acceptability of the test were met, this study is considered to be valid.
Results of the respiration inhibition test
On the basis of the effective concentrations describing the respiration inhibition of activatedsludge caused by the test substance,Copolymer of aniline and formaldehyde, hydrogenated, the EC50was found to be:
EC50= 187 mg.L-1(95% confidence interval: 137 – 251 mg.L-1)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.