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Diss Factsheets
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EC number: 431-060-1 | CAS number: 153719-38-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: expert statement
- Adequacy of study:
- key study
- Study period:
- 1999-04-09
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No gudieline-conform study. Two-pages expert statement prepared by the former notifier Novartis Crop Protection AG, Basel.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- expert statement / review summary based on available study results.
- GLP compliance:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 431-060-1
- EC Name:
- -
- Cas Number:
- 153719-38-1
- Molecular formula:
- Hill formula: C4H8N4O3 CAS formula: C4H8N4O3
- IUPAC Name:
- 3-methyl-N-nitro-3,6-dihydro-2H-1,3,5-oxadiazin-4-amine
- Details on test material:
- not applicable
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: not applicable
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not applicable
Administration / exposure
- Route of administration:
- other: not applicable
- Vehicle:
- other: not applicable
- Details on exposure:
- not applicable
- Duration and frequency of treatment / exposure:
- not applicable
Doses / concentrations
- Remarks:
- Doses / Concentrations:
not applicable
- No. of animals per sex per dose / concentration:
- not applicable
- Control animals:
- other: not applicable
- Positive control reference chemical:
- not applicable
- Details on study design:
- not applicable
- Details on dosing and sampling:
- not applicable
- Statistics:
- not applicable
Results and discussion
- Preliminary studies:
- not applicable
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- In animals CA2343A is assumed to be absorbed rapidly from the gastrointestinal tract into the systemic circulation. The extent of absorption will probably be reasonable to well.
- Details on distribution in tissues:
- Degradation is assumed to take place with a significant amount of unchanged compound excreted. Rapid and almost complete excretion of CA 2343 A together with its metabolites is espected, mainly via the urine, and as a consequence tissue residues will be low. Therefore no retention and accumulation of CA 2343 A and/or its metabolites is assumed.
- Details on excretion:
- Degradation is assumed to take place with a significant amount of unchanged compound excreted. Rapid and almost complete excretion of CA 2343 A together with its metabolites is espected, mainly via the urine, and as a consequence tissue residues will be low. Therefore no retention and accumulation of CA 2343 A and/or its metabolites is assumed.
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- Cleavage of the oxadiazine ring to the corresponding nitroguanidine compound is anticipated to be the major metabolic reaction (1) (see figure in the attached original expert statement). Expected minor reactions are hydrolytic and/or oxidative cleavage of the guanidine group to the corresponding urea (2), demethylation of the guanidine group to the corresponding desmethyl compound (3), and cleavage of the nitroguanidine group yielding a
guanidine derivative (4), most probably via short living intermediates like hydroxylamine- and hydrazine-derivates.
The short living intermediates are probably prone to acylation. Most of the metaholites are expected to be the result of more than one of the above reactions. Cleavage of the oxadiazine ring gives rise to minor transformations proceeding rapidly to small molecules and ultimately to CO2. The small
molecules may enter, at least partially, the general metabolism.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
No retention and accumulation of CA 2343 A and/or its metabolites is assumed. - Executive summary:
The purpose of this expert statement was to prepare a toxicokinetic assessment of test substance CA 2343 (oxadiazinamine). For preparing the toxicokinetic assement no specific guideline was followed, the expert statement primarily is based on summarizing the results from availble studies. Some details on absorption and excretion of the test substance, as well as on its assumed metabolites are given in the report. In conclusion, no retention and accumulation of CA 2343 A and/or its metabolites is assumed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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