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EC number: 814-217-0 | CAS number: 353258-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil microorganisms
Administrative data
- Endpoint:
- toxicity to soil microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 216 (Soil Microorganisms: Nitrogen Transformation Test)
- Version / remarks:
- 2000
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 217 (Soil Microorganisms: Carbon Transformation Test)
- Version / remarks:
- 2000
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
- Cas Number:
- 353258-35-2
- Molecular formula:
- C9H4ClF3N2O2
- IUPAC Name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
1
- Specific details on test material used for the study:
- Test substance: IN-QEK31-011
Batch No.: SG0312574
Purity: 98.2%
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- yes
- Remarks:
- Quartz sand
Test organisms
- Test organisms (inoculum):
- soil
Study design
- Total exposure duration:
- 28 d
Test conditions
- Test temperature:
- 20 - 22°C
- Moisture:
- 44 - 50% of water holding capacity
- Organic carbon content (% dry weight):
- 1.22
- Nominal and measured concentrations:
- 15.67 mg and 156.7 mg test item/kg soil dry weight.
- Reference substance (positive control):
- yes
- Remarks:
- Sodium chloride (tested at least once a year)
Results and discussion
Effect concentrations
- Key result
- Duration:
- 28 d
- Basis for effect:
- other: The test item has no effect on nitrogen transformation or respiration at concentrations up to and including 156.7 mg test item/kg soil dry weight
- Results with reference substance (positive control):
- In the most recent study, the reference item sodium chloride has long term influence on soil microflora and confirms the sensitivity of the test system.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test item has no effect on nitrogen transformation or respiration at concentrations up to and including 156.7 mg test item/kg soil dry weight
- Executive summary:
A laboratory soil microflora study was conducted in a loamy sand soil to determine the effects of the test item on nitrogen transformation and soil respiration. This study was conducted according to OECD-Guideline for the Testing of Chemicals, Soil Microorganisms: Nitrogen Transformation Test, Guideline 216 and OECD-Guideline for the Testing of Chemicals, Soil Microorganisms: Carbon Transformation Test, Guideline 217, (21 January 2000).
The test item was directly applied to the soil (mixed with quartz sand) at nominal test concentrations of 15.67 mg and 156.7 mg test item/kg soil dry weight. The control consisted of soil mixed with quartz sand.
Deviations in nitrate levels and nitrate formation rates in soil treated with up to and including 156.7 mg test item/kg soil dry weight were low at day 44 and all rates were <25% indicating no effect occurred in nitrogen transformation. Deviations of short-term respiration in soil treated with up to and including 156.7 mg test item/kg soil dry weight were low at day 28 and all rates were < 25% indicating no effect occurred in carbon transformation.
The test item has no effect on nitrogen transformation or respiration at concentrations up to and including 156.7 mg test item/kg soil dry weight (deviations between treatments and controls for both nitrogen and carbon transformation tests were in the range of 25% deviation as specified by the OECD guidelines at day 44 and 28, respectively). The results indicate that there is a large margin of safety for the test item in microbial processes in soil.
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