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EC number: 814-217-0 | CAS number: 353258-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional information on environmental fate and behaviour
Administrative data
- Endpoint:
- additional information on environmental fate and behaviour
- Remarks:
- storage stability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 506: Stability of Pesticide Residues in Stored Commodities
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: European Communities Guideline for the Generation of Data Concerning Residues, as provided in Annex II, Part A, Section 6 and Annex III, Part A, Section 8 of EC Commision Directive 91/414/EEC.
- Deviations:
- no
- GLP compliance:
- yes
- Type of study / information:
- storage stability
Test material
- Reference substance name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
- Cas Number:
- 353258-35-2
- Molecular formula:
- C9H4ClF3N2O2
- IUPAC Name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
1
- Specific details on test material used for the study:
- Test substance: IN-QEK31
Batch No.: IE114893-105
Purity: 98.6%
Results and discussion
Any other information on results incl. tables
Table 1: Parent recoveries
| IN-QEK31 |
Fresh fortifications | 89.8 ± 9.0 |
Aged fortifications | 91.8 ± 11.9 |
Applicant's summary and conclusion
- Conclusions:
- Residues of IN-QEK31 are stable when stored frozen in both soil types at approximately -20°C for up to 24 months.
- Executive summary:
A number of field and laboratory studies were conducted with DPX-Q8U80 in which the soils containing residues of the parent compound and its metabolites were stored frozen while awaiting analysis. In order to demonstrate that the residues were stable during freezer storage, a storage stability study was conducted on two representative soils which were treated with DPX-Q8U80 and its soil metabolites (IN-QEK31, IN-VM862, IN-RYC33, IN-F4106, IN-A5760 and IN-REG72) and stored under conditions similar to those used for storage of samples for the field and laboratory studies. These fortified samples were analyzed at 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 21 and 24 months. This stability study was designed to cover the longest interval between sample collection and the analysis of these soils for the residues of DPX-Q8U80 and its soil degradates, which were stored frozen at approximately -20°C.
Two soils, representative of field sites chosen for the field dissipation studies were selected for this study. The soils were obtained from the field study sites in Italy [Graffignana] (used for study reported in DuPont-36980), and France [Nambsheim] (used for study DuPont-36981). Two sets of soil samples, Set A and Set B, were fortified with the respective analytes at a level of 20 μg/kg of each analyte, and stored at approximately -20ºC. Set A samples were fortified with (DPX-Q8U80, IN-QEK31, IN-VM862 and IN-RYC33) and Set B with (DPX-Q8U80, IN-F4106, IN-A5760 and IN-REG72). At each analysis time point, fresh soil samples were fortified with all respective analytes at a level of 20 μg/kg. The samples were analyzed at ca 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 21 and 24 months.
Samples were analyzed using the analytical method which had been used in the analysis of the terrestrial field dissipation study samples. Residues of DPX-Q8U80, and soil metabolites IN-QEK31, IN-VM862, IN-RYC33, IN-F4106, IN-A5760 and IN-REG72 were extracted from soil by a 2 step sequential extraction procedure. Extraction solution used was 1/1 (v/v) 2% formic acid (aq)/acetonitrile. The two extractions were combined and diluted to 35mL with water. A 7 mL aliquot was removed from each extract before passing it through Oasis HLB SPE 6 mL (0.5g) cartridge. The cartridges were rinsed with 5 mL 20/80 (v/v) acetonitrile/water prior to be eluted using 12mL of 50mM ammonium formate in 50/50 (v/v) acetone/acetonitrile. Collected eluates were evaporated under a flow of nitrogen to 2 mL in a heated dry-block set at 35 ºC. Once reached the volume, an aliquot of 3 mL of methanol was added and the extracts were concentrated to 2 mL. These samples were then diluted up to 10 mL with water and filtered prior to be analyzed using reverse phase HPLC separation coupled to tandem mass spectrometry (LC-MS/MS).
Fresh fortified soil samples were analyzed concurrently in each analysis set. The average recoveries in the freshly fortified and frozen fortified soil samples for both soil types were comparable over the entire 24-month period.
Examination of average recoveries and standard deviations for DPX-Q8U80 and soil metabolites shows that the individual fresh fortification recoveries, as well as the frozen fortification recoveries, were in general normally distributed and within the range of method capability. The recoveries for all analytes at each sampling interval were also generally within the range of expected variability for the analytical method. For all analytes there was no discerable trend of decreasing recoveries in the frozen stored samples over time.
It can be concluded that the residues ofDPX-Q8U80 and soil metabolites are stable in frozen soil over 24 months.
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