Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-634-0 | CAS number: 123-54-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 986
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
- Principles of method if other than guideline:
- Undiluted 2,4-pentanedione was applied on the shaved dorsal skin (25 cm2) of 3-5 male or female New Zealand White rabbits/group (occlusive contact for 24 h; 14 d postapplication period; 5 doses).
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Details on test material:
- Purity: >99%
Physical state: yellow, transparent non-viscous liquid
Lot No.: 496-500
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Weight: 2-3 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 25 cm2
TEST MATERIAL
- Amounts applied: 0.5 - 10 mL/kg bw
- Concentration: undiluted
- Constant volume or concentration used: no
- For solids, paste formed: no - Duration of exposure:
- 24 h
- Doses:
- Males: only in males 10 and 5 mL/kg bw, equivalent to 9700 and 4850 mg/kg bw
Males and females: 2, 1 and 0.5 mL/kg bw, equivalent to 1940, 970 and 485 mg/kg bw tested - No. of animals per sex per dose:
- 0.5, 1, 2 mL/kg bw: 5 males and 5 females
5 and 10 mL/kg bw: 3-5 males (not further specified) - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 370 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 780 - 2 420
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 790 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 570 - 1 090
- Mortality:
- No animal died within the lowest dose group, but 1/5 males and 4/5 females died in the 1 mL/kg dose group, 4/5 males and 5/5 females in the 2 mL/kg dose group and all males in the two highest dose groups of 5 and 10 mL/kg. Death occurred within 1-24 h after application.
- Clinical signs:
- other: Signs of toxicity at 1 mL/kg or more were: dilated pupils, salivation 10 mL/kg bw: convulsions; local erythema, edema and necrosis (persisted for 1-7 d) and scab formation at day 14.
- Gross pathology:
- Dead animals showed red mottled lungs, patchy congestion of tracheal mucosa, and a few stomachs with superficial black foci at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Under the evaluated conditions, LD50 values for male rabbits of 1370 mg/kg bw and females of 790 mg/kg bw were determined.
- Executive summary:
New Zealand White rabbits were dermally exposed under occlusive conditions to the test substance with the application of 2, 1 and 0.5 mL/kg bw, equivalent to 1940, 970 and 485 mg/kg bw tested to male and female rabbits (5/sex/dose). Additionally only in males 10 and 5 mL/kg bw, equivalent to 9700 and 4850 mg/kg bw were tested.
No animal died within the lowest dose group, but 1/5 males and 4/5 females died in the 1 mL/kg dose group, 4/5 males and 5/5 females in the 2 mL/kg dose group and all males in the two highest dose groups of 5 and 10 mL/kg. Death occurred within 1-24 h after application.
Signs of toxicity at 1 mL/kg or more were: dilated pupils, salivation
10 mL/kg bw: convulsions; local erythema, edema and necrosis (persisted for 1-7 d) and scab formation at day 14.No effect on bodyweight was observed in the surviving animals.
Dead animals showed red mottled lungs, patchy congestion of tracheal mucosa, and a few stomachs with superficial black foci at necropsy.
Under the evaluated conditions, LD50 values for male rabbits of 1370 mg/kg bw and females of 790 mg/kg bw were determined.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)
Čeprav agencija ECHA veliko spletnega gradiva objavlja v vašem jeziku, je ta stran deloma še vedno v angleščini. Več informacij o večjezikovni praksi agencije.
Dobrodošli na spletišču agencije ECHA Vsebina na tej strani ni v celoti podprta z brskalnikom Internet Explorer 7 (in starejšimi različicami). Prosimo, nadgradite vaš brskalnik Internet Explorer na novejšo različico.
Ta stran uporablja piškotke za zagotavljanje najboljše možne uporabniške izkušnje na našem spletišču.
Preberite več o tem, kako uporabljamo piškotke.