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Diss Factsheets
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EC number: 204-634-0 | CAS number: 123-54-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 986
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Dynamic study: Groups of 5 male and 5 female Hilltop-Wistar albino rats were exposed for four hours to dynamically generated vapour of 2,4-pentanedione. Concentrations tested were 628, 919, 1231 and 1508 ppm (corresponding to 2619, 3823, 5133 and 6288 mg/m3). Chamber concentrations were concurrently analysed throughout each 4-hour exposure by GC. Postexposure period 14 d, body weight determined at 0, 7 and 14 d postexposure.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Details on test material:
- Purity: 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Hilltop-Wistar albino rats [HLA(WI)BR]
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- Chamber concentrations concurrently analysed throughout each 4-hour exposure by GC.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- 628, 919, 1231 and 1508 ppm (corresponding to 2619, 3823, 5133 and 6288 mg/m3)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Body weight was determined 0, 7, and 14 days postexposure.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 5 104 mg/m³ air (analytical)
- Based on:
- test mat.
- 95% CL:
- >= 4 432 - <= 5 876
- Exp. duration:
- 4 h
- Mortality:
- Dynamic exposure: The results indicate that the 4 hour dynamic LC50 (95 % confidence limits) for 2,4-pentanedione (combined male and female) is 1224 (1063 to 1409) ppm (corresponding to 5104 (4432 - 5876) mg/m3). The LC50 was determined for combined male and female rat. Deaths were observed with both male and female rats exposed to concentrations of 1508 and 1231 ppm (mortality 8/10 and 6/10). Deaths occurred mostly during exposure or within 24 hours post-exposure (1 exception on day 3 in male rats in the 1508 ppm group). No mortalities were observed with rats exposed to dynamic concentrations of 919 or 628 ppm.
- Clinical signs:
- other: Clinical signs observed in rats of the 1508 and 1231 ppm exposure groups included periocular, perinasal and perioral wetness and encrustation, forced respiration, distended abdomen, tremors, ataxia, decreased motor activity, a negative tail and toe pinch
- Gross pathology:
- Necropsy of rats that died: red lungs, dark livers, gas-filled stomachs. No effects on sacrificed survivors.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Under the evaluated conditions, an LC50 value of 5104 mg/m³ was determined (male/female combined).
- Executive summary:
The results indicate that the 4 hour dynamic LC50 (95 % confidence limits) for 2,4-pentanedione (combined male and female) is 1224 (1063 to 1409) ppm (corresponding to 5104 (4432 - 5876) mg/m3). The LC50 was determined for combined male and female rat. Deaths were observed with both male and female rats exposed to concentrations of 1508 and 1231 ppm (mortality 8/10 and 6/10). Deaths occurred mostly during exposure or within 24 hours post-exposure (1 exception on day 3 in male rats in the 1508 ppm group). No mortalities were observed with rats exposed to dynamic concentrations of 919 or 628 ppm.
Clinical signs observed in rats of the 1508 and 1231 ppm exposure groups included periocular, perinasal and perioral wetness and encrustation, forced respiration, distended abdomen, tremors, ataxia, decreased motor activity, a negative tail and toe pinch. Deceased animals had red lungs, dark livers and gas-filled stomachs. The surviving animals did not show any abnormalities in necropsy.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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