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EC number: 701-402-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dimethyl [3-[(hydroxymethyl)amino]-3-oxopropyl]phosphonate
- EC Number:
- 243-528-9
- EC Name:
- Dimethyl [3-[(hydroxymethyl)amino]-3-oxopropyl]phosphonate
- Cas Number:
- 20120-33-6
- Molecular formula:
- C6H14NO5P
- IUPAC Name:
- dimethyl [3-[(hydroxymethyl)amino]-3-oxopropyl]phosphonate
- Reference substance name:
- Dimethyl (3-amino-3-oxopropyl)phosphonate
- EC Number:
- 219-765-9
- EC Name:
- Dimethyl (3-amino-3-oxopropyl)phosphonate
- Cas Number:
- 2526-69-4
- Molecular formula:
- C5H12NO4P
- IUPAC Name:
- dimethyl (3-amino-3-oxopropyl)phosphonate
- Test material form:
- liquid: viscous
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Test system: Rabbit, Chbblbm: NZW (SPF)
Source: BRL, Biological Research Laboratories Ltd., Wölferstrasse 4, CH-4414 Füllinsdorf
Age at start of treatment: male: 15 weeks, females: 16 weeks
Body weight at start of treatment: male: 3.0 kg, females: 3.1 - 3.3 kg
Identification: By unique cage number and corresponding ear tags.
Acclimatization: four days under laboratory conditions after veterinary examination.
Conditions
Standard Laboratory Conditions. Air-conditioned with 10-15 air changes per hour and hourly monitored environment with a temperature of 20 ± 3 °C, a relative humidity between 40-70 % (values above 70 % during cleaning process possible), 12 hours artificial fluorescent light (approx. 100 Lux)/12 hours dark, music during the light period.
Accommodation
Individually in stainless steel cages (size: 35.5 x 55.5 x 45 cm) equipped with an automatic cleaning and drinking system (Dipl. Ing. W. Ehret GmbH, D-7830 Emmendingen).
Diet
Pelleted standard Kliba 341, Batch 66/91 rabbit maintenance diet ("Kliba", Kiingentalmuehle AG, CH-4303 Kaiseraugst), ad libitum. Results of analysis for contaminants are included in this report.
Water
Community tap water from Itingen, ad libitum. Results of bacteriological, chemical and contaminant analyses are included in this report.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- The test article was applied undiluted as delivered by the sponsor.
- Duration of treatment / exposure:
- On test day 1, 0.1 ml of the test article (undiluted) was placed in the conjunctival sac of the left eye of each animal after gently pulling the lower lid away from the eyeball. The lids were then gently held together for about one second to prevent loss of the test article. The right eye remained untreated and served as the reference control.
- Observation period (in vivo):
- The eyes of each animal were examined for ocular irritation 1, 24, 48 and 72 hours and 7 days after administration. The irritation was assessed according to the Draize numerical scoring system. The corrosive properties of the test article and the staining of the treated eye were described and recorded.
- Number of animals or in vitro replicates:
- 2 females and 1 male
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): none
SCORING SYSTEM: draize scoring
OBSERVATIONS
Viability/Mortality and Clinical Signs: Daily.
Body Weights: At the start of acclimatization, at day 1 of test (application day) and at termination of observation.
Irritation Scores:
The eyes of each animal were examined for ocular irritation 1, 24, 48 and 72 hours and 7 days after administration. The irritation was assessed according to the following numerical scoring system. The corrosive properties of the test article and the staining of the treated eye were described and recorded.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72h
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48h
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7d
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72h
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7d
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7d
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item DMPPA_701-402-5 is considered as non-irritant to the eye.
- Executive summary:
The primary irritation potential of the test material was investigated by instillation of DMPPA_701-402-5 into one eye of each three young adult New Zealand rabbits. The treated eyes were not rinsed after substance application. Scoring of irritation effects were performed 1, 24, 48, 72 hours and 7 days after installation. No staining of the cornea and conjunctivae of the treated eyes by pigment or coloring of the test article was observed. Generally slight diffuse corneal opacity was observed in all three animals between 1 hour, 24 hours and 72 hours of observation respectively, however the scores were below threshold required for classification as per CLP criteria. Hence, the test article has to be classified as not irritant to the eye of rabbits.
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