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EC number: 837-106-9 | CAS number: 71472-57-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 January 2019 - 18 June 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- 13 April 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- Commission Regulation (EC) No 440/2008 (as amended), 30 May 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- - pH: 4
- Composition of buffer:
Citric acid 6 (mmol dm-3);
Sodium chloride 4 (mmol dm-3);
Sodium hydroxide 7 (mmol dm-3).
- pH: 7
- Composition of buffer:
Disodium hydrogen orthophosphate (anhydrous) 3 (mmol dm-3);
Potassium dihydrogen orthophosphate 2 (mmol dm-3);
Sodium chloride 2 (mmol dm-3).
- pH: 9
- Composition of buffer:
Boric acid 5 (mmol dm-3);
Potassium chloride 5 (mmol dm-3);
Sodium hydroxide 2 (mmol dm-3). - Details on test conditions:
- Preliminary Test/Tier 1:
Stock solutions of test item were prepared at a nominal concentration of 200 mg/L in the three buffer solutions; a 1% co-solvent of methanol was used to aid solubility. The stock solutions were split into individual glass vessels and sealed with minimal headspace for each data point. These sample solutions were maintained at 50.0 ± 0.5 °C for a period of 120 hours while being shielded from light.
Preliminary Test/Tier 1 (pH 4 Repeat):
A stock solution of test item was prepared at a nominal concentration of 200 mg/L in pH 4 buffer solution; a 1% co-solvent of acetonitrile was used to aid solubility. The stock solutions were split into individual plastic vessels and sealed with minimal headspace for each data point. These sample solutions were maintained at 50.0 ± 0.5 °C for a period of 120 hours while being shielded from light.
Tier 2:
Results from the preliminary test/tier 1 indicated it was necessary to undertake further testing at pH 4. A stock solution of test item was prepared at a nominal concentration of 200 mg/L in pH 4 buffer solution; a 1% co-solvent of acetonitrile was used to aid solubility. The stock solutions were split into individual deactivated glass vessels and sealed with minimal headspace for each data point. These sample solutions were maintained at 50.0 ± 0.5 °C,
60 ± 0.5 °C and 70 ± 0.5 °C for a period of 336, 215 and 96 hours respectively while being shielded from light. - Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 200 mg/L
- Remarks:
- Tier 1 test / co-solvent methanol
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 200 mg/L
- Remarks:
- Tier 1 test / co-solvent methanol
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 200 mg/L
- Remarks:
- Tier 1 test / co-solvent methanol
- Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 200 mg/L
- Remarks:
- Tier 1 test (pH 4 repeat) / co-solvent acetonitrile
- Duration:
- 336 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 200 mg/L
- Remarks:
- Tier 2 test / co-solvent acetonitrile
- Duration:
- 215 h
- pH:
- 4
- Temp.:
- 60 °C
- Initial conc. measured:
- 200 mg/L
- Remarks:
- Tier 2 test / co-solvent acetonitrile
- Duration:
- 96 h
- pH:
- 4
- Temp.:
- 70 °C
- Initial conc. measured:
- 200 mg/L
- Remarks:
- Tier 2 test / co-solvent acetonitrile
- Number of replicates:
- Duplicate sample solutions were taken initially and from the waterbath at various time points. The pH of each solution was recorded.
- Positive controls:
- no
- Negative controls:
- no
- Test performance:
- Validation:
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 25 to 150 mg/L for the methanol:pH 4 buffer solution (50:50 v/v) matrix. The result was satisfactory with a correlation coefficient (r) of 1.000 being obtained.
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 10 to 250 mg/L for the methanol:pH 7 buffer solution (50:50 v/v) matrix. The result was satisfactory with a correlation coefficient (r) of 1.000 being obtained. - Transformation products:
- no
- Details on hydrolysis and appearance of transformation product(s):
- The test item was considered to be hydrolytically stable at pH 4, pH 7 and pH 9 under the conditions of the test.
- Key result
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- 115 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other:
- Remarks:
- after being stored in glass vessels and using a methanol co-solvent
- Key result
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- 1 510 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other:
- Remarks:
- after being stored in glass vessels and using a methanol co-solvent
- Key result
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- 575 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other:
- Remarks:
- after being stored in glass vessels and using a methanol co-solvent
- Key result
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- 57.3 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other:
- Remarks:
- Repeated. stored in plastic vessels and using acetonitrile co-solvent
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test item was considered to be hydrolytically stable at pH 4, pH 7 and pH 9 under the conditions of the test. However, a decrease in concentration of the test item in solution was observed, especially at pH 4, but this finding was assessed to have been due to oxidation.
Reference
Preliminary Test/Tier 1:
The test item concentrations at the given time points, after being stored in glass vessels and using a methanol co-solvent,are shown in the following tables:
pH 4 at 50 ºC
Time (Hours) |
Concentration (mg/L) |
% of Mean Initial Concentration |
||
A |
B |
A |
B |
|
0 |
256 |
256 |
100 |
100 |
22 |
215 |
215 |
83.9 |
83.8 |
120 |
123 |
123 |
47.8 |
47.9 |
pH 4 at 50 °C half-life: 115 hours
pH 7 at 50 ºC
Time (Hours) |
Concentration (mg/L) |
% of Mean Initial Concentration |
||
A |
B |
A |
B |
|
0 |
265 |
265 |
100 |
100 |
22 |
262 |
262 |
98.8 |
98.8 |
120 |
251 |
251 |
94.6 |
94.5 |
pH 7 at 50 °C half-life: 1.51 x 103hours
pH 9 at 50 ºC
Time (Hours) |
Concentration (mg/L) |
% of Mean Initial Concentration |
||
A |
B |
A |
B |
|
0 |
286 |
286 |
100 |
100 |
22 |
284 |
284 |
99.3 |
99.2 |
120 |
250 |
249 |
87.2 |
87.0 |
pH 9 at 50 °C half-life: 575 hours
The test item concentrations at the given time points, after being stored in plastic vessels and using an acetonitrile co-solvent, are shown in the following table:
Repeated pH 4 at 50 ºC
Time (Hours) |
Concentration (mg/L) |
% of Mean Initial Concentration |
||
A |
B |
A |
B |
|
0 |
193 |
193 |
99.9 |
100 |
120 |
46.2 |
44.0 |
24.0 |
22.8 |
pH 4 at 50 °C result: half-life = 57.3 hours
Tier 2
The test item concentrations at the given time points are shown in the following tables:
pH 4 at 50 ºC
Time (Hours) |
Concentration (mg/L) |
% of Mean Initial Concentration |
||
A |
B |
A |
B |
|
0 |
240 |
241 |
99.9 |
100.1 |
23 |
190 |
187 |
78.7 |
77.8 |
48 |
159 |
153 |
66.0 |
63.6 |
96 |
123 |
125 |
51.2 |
51.9 |
168 |
93.9 |
92.0 |
39.0 |
38.2 |
240 |
74.7 |
74.8 |
31.0 |
31.1 |
336 |
74.3 |
75.2 |
30.9 |
31.2 |
pH 4 at 60 ºC
Time (Hours) |
Concentration (mg/L) |
% of Mean Initial Concentration |
||
A |
B |
A |
B |
|
0 |
264 |
265 |
99.8 |
100.2 |
24 |
198 |
199 |
74.8 |
75.4 |
47 |
155 |
158 |
58.7 |
59.9 |
52 |
150 |
152 |
56.9 |
57.4 |
72 |
139 |
138 |
52.4 |
52.1 |
96 |
112 |
112 |
42.5 |
42.5 |
165 |
81.7 |
81.6 |
30.9 |
30.9 |
215 |
65.0 |
65.0 |
24.6 |
24.6 |
pH 4 at 70 ºC
Time (Hours) |
Concentration (mg/L) |
% of Mean Initial Concentration |
||
A |
B |
A |
B |
|
0 |
240 |
241 |
99.9 |
100.1 |
3 |
228 |
228 |
94.8 |
94.7 |
6 |
215 |
217 |
89.4 |
90.0 |
22 |
162 |
162 |
67.5 |
67.3 |
28 |
150 |
151 |
62.4 |
62.7 |
48 |
117 |
115 |
48.7 |
47.6 |
54 |
106 |
109 |
44.2 |
45.2 |
75.5 |
82.4 |
88.0 |
34.2 |
36.6 |
96 |
73.8 |
75.5 |
30.7 |
31.4 |
Description of key information
The hydrolysis as a function of pH of the test substance has been evaluated using a procedure designed to be compatible with both Method C.7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008, and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004. The test item was considered to be hydrolytically stable at pH 4, pH 7 and pH 9 under the conditions of the test. However, a decrease in concentration of the test item in solution was observed, especially at pH 4, but this decrease was assessed to have been due to oxidation and not hydrolysis.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 510 h
- at the temperature of:
- 50 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.