Registration Dossier
Registration Dossier
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EC number: 203-464-4 | CAS number: 107-12-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Prehled Prumyslove Toxikologie; Organicke Latky
- Author:
- Marhold, J.
- Year:
- 1 986
- Bibliographic source:
- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No further details are provided but this study has been peer reviewed by the US National Institute for Occupational Safety and Health (NIOSH) and is therefore considered a credible source.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Propiononitrile
- EC Number:
- 203-464-4
- EC Name:
- Propiononitrile
- Cas Number:
- 107-12-0
- Molecular formula:
- C3H5N
- IUPAC Name:
- propanenitrile
Constituent 1
Test animals
- Species:
- rabbit
Results and discussion
In vivo
Results
- Basis:
- mean
- Time point:
- 24 h
- Remarks on result:
- positive indication of irritation
- Remarks:
- Mild irritation of the skin was observed after 24 hours at a dose of 500 mg proprionitrile
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
- Conclusions:
- Moderate effects on the eyes of rabbits were observed after 24 hours at a dose of 100 mg.
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