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Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Version / remarks:
Adopted: 28, July, 2015
Qualifier:
according to guideline
Guideline:
other: Testing Guidelines for Studies of Chemicals
Version / remarks:
Notification No. 2018-12, issued by the National Institute of Environmental Research, Republic of Korea on 9, April, 2018
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
482-200-1
EC Name:
-
Cas Number:
1184-10-7
Molecular formula:
C36H30N3O6P3
IUPAC Name:
hexaphenoxy-1,3,5,2λ⁵,4λ⁵,6λ⁵-triazatriphosphinine
Test material form:
solid
Specific details on test material used for the study:
Lot No. 180705
Purity: 99.08%
Appearance: White crystal
Storage condition: Room temperature

Test animals

Species:
rabbit
Details on test animals or test system and environmental conditions:
Species: New-Zealand white-Rabbit
Sex, number and body weight range (on administration): Males, 3 rabbits, 2.334-2.574 kg
Temperature: 17.0-23.2 oC(average: 19.5 oC)
Relative humidity: 30.0-70.0%(average:44.5%)
Air changes: 10-15 times/hour
Lighting: 12 hour light/dark cycle
Intensity of illumination: 150-300 Lux

Test system

Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
0.5g
Duration of treatment / exposure:
4 hours
Observation period:
3 days
Number of animals:
3
Details on study design:
Initial test were performed with one animal. The test item was applied to the animal three times in sequence. When ovserving the first three minutes and one hour after the applicaiton was do not observed skin irritation. Applied to the other parts of the third for 4 hours the skin reactions were evaluated scores. Since corrosive effect was not observed in the initial test, two additional animals were used for the confirmatory test. Skin reactions of each animal were evaluated applying 4 hours. Also the set control region does not apply the test item in the same animal.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
0
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Max. score:
0
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
0

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
HPCTP does not belong to the category planned in this study. Therefore test item was determined to "Not classified".
Executive summary:

This study was conducted to evaluate the dermial irritant and/or corrosive response of the test item, Phenoxycycloposphazene. A total of 3 rabbits was treated with test item, and the skin reaction was observed for a maximunm of 3 day.

The test results are shown below.

1) Deaths and abnormal symptoms by test item were not observed.

2) Change of body weight by test item was not observed.

3) In the initial test, corrosive response was not observed.

4) In the initial and confirmatory test, the mean score of the three animals was 0.0, and the mean score of the two high-score animals among the three animals was 0.0.

5) Skin irritation by the test item lasted for up to 3 days.

6) Other reaction by the test item was not observed.

According to the above results, test item, Phenoxycycloposphazene does not belong to the category planned in this study. Therefore test item was determined to "Not classified".