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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation, other
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
Jusqu'à 1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicity & Health Hazard Summary, Material Safety Data Sheet and Toxicity Reports on 2,4-Pentanedione with Attachments
Author:
Eastman Kodak Comp.
Year:
1979
Bibliographic source:
HS&HFL No. 79-0359. USEPA New Doc. I.D. 86-920000007 (1986)
Reference Type:
publication
Title:
2,4-Pentanedione. CAS N°: 123-54-6
Author:
OECD Organisation for Economic Co-operation and Development
Year:
2001
Bibliographic source:
SIDS Initial Assessment Report for SIAM 13 (Paris, France, in June) United Nations Environment Programme (UNEP) Publications, Nairobi, Kenya. 82 p. URL https://hpvchemicals.oecd.org/ui/handler.axd?id=AF8877C9-8DFB-45E0-8188-492EBA68CDAE

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
Principles of method if other than guideline:
5 cochons d'inde testés
GLP compliance:
not specified
Type of study:
not specified
Justification for non-LLNA method:
Pas applicable

Test material

Constituent 1
Reference substance name:
Pentane-2,4-dione
EC Number:
204-634-0
EC Name:
Pentane-2,4-dione
Cas Number:
123-54-6
Molecular formula:
C5H8O2
Specific details on test material used for the study:
Non disponible

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
Non disponible

Results and discussion

Positive control results:
Non disponible

In vivo (non-LLNA)

Results
Reading:
1st reading
Hours after challenge:
24
Group:
test chemical
Dose level:
Non disponible
No. with + reactions:
1
Total no. in group:
5
Clinical observations:
Réaction faible observée chez 1 animal
Remarks on result:
no indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
other: Résultats ambigus ne permettant pas une classification claire de la 2,4 pentanedione concernant la sensibilisation de la peau.
Conclusions:
Les résultats de cette étude ne permettent pas une classification claire de la 2,4 pentanedione concernant la sensibilisation de la peau.
Executive summary:

Dans cette étude, 5 cochons d'inde ont été soumis à un test de sensibilisation de la peau standard.

1 cochon d'inde sur 5 a montré une réponse faible tandis que les 4 animaux restants sont restés normaux

Le résultat global de l'étude a été jugé ambigu par les auteurs de l'étude pour permettre une classification