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EC number: 289-621-8 | CAS number: 89957-99-3 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Boswellia papyrifera, Burseraceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- From 2019-01-04 to 2019-01-04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- See attached documents for full details.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
- Deviations:
- yes
- Remarks:
- Calculation method
- Principles of method if other than guideline:
- The growth inhibition of algae was determined using a validated calculation method for the Mechanism of Action (MechoA) in question (MechoA 1.1, i.e. non-polar narcosis). The QSAR model is based on validated data from a training set of 40 chemicals derived from 72-hour test on algae, for which the concentrations of the test item had been determined by chemical analyses over the test period.
- GLP compliance:
- no
- Specific details on test material used for the study:
- None.
- Analytical monitoring:
- no
- Details on sampling:
- Not applicable.
- Vehicle:
- no
- Details on test solutions:
- Not applicable.
- Test organisms (species):
- other: algae spp.
- Details on test organisms:
- Results from the following species were used in the regression:
- Desmodesmus subspicatus
- Pseudokirchneriella subcapitata
- Scenedesmus quadricauda - Test type:
- other: Calculation method
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Remarks on exposure duration:
- 72h-ErL50 (effective loading rate of WAF)
- Post exposure observation period:
- Not applicable.
- Hardness:
- Not applicable.
- Test temperature:
- Not applicable.
- pH:
- Not applicable.
- Dissolved oxygen:
- Not applicable.
- Salinity:
- Not applicable.
- Conductivity:
- Not applicable.
- Nominal and measured concentrations:
- Not applicable.
- Details on test conditions:
- Calculation method.
- Reference substance (positive control):
- not required
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EL50
- Effect conc.:
- 15 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other:
- Remarks:
- based n typical composition
- Details on results:
- Not applicable.
- Results with reference substance (positive control):
- Not applicable.
- Reported statistics and error estimates:
- Not applicable.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The following toxicity value has been estimated for the registered substance: 72h-ErL50 = 15 mg/L.
- Executive summary:
A calculation method was used to predict the inhibition of algal growth exposed to the test item OLIBANUM OIL (Bowsellia papyrifera), using the WAF method. This calculation method predicts the endpoint value which would be expected when testing the substance under experimental conditions in a laboratory following the Guideline for Testing of Chemicals No. 201, "Freshwater Alga and Cyanobacteria, Growth Inhibition Test", referenced as Method C.3 of Commission Regulation No. 440/2008 (2) adapted for testing of a mixture using the WAF method. The criterion measured was the median effective loading rate of the mixture ErL50 (Median Effective Loading for specific growth rate), a statistically derived loading rate which is expected to cause 50% inhibition of intrinsic rate of growth of the test system within a period of 72 hours.
The result below is the toxicity value anticipated during a 72-hour ErL50study on algae based on the composition of OLIBANUM OIL (Bowsellia papyrifera).
The 72-hour ErL50is calculated as follows:
Composition
Time (h)
ErL50(mg test item.L-1)
typical
72
15
Reference
Determination of the Analytically Measurable Aqueous Phase (AMAP).
Using the model, the specific concentration of each constituent in the WAF can be accurately determined at any loading rate taking into account the original composition of the mixture and the new corrected limit of solubility of
each constituent. The sum of these concentrations, the AMAP, is equivalent to the concentration of all constituents that would be measured in a WAF test. For a given loading rate, the loaded concentration of each constituent is
compared to its respective solubility limit. If one is higher than the solubility limit then it is considered that the concentration of the constituent will be equal to its solubility limit. If lower, the true loading concentration is considered. Provided this adapted water solubility limits for each consitutents. analytically measurable concentrations in aqueous solutions expected from known WAF loading rates of characterised mixtures can be calculated. The AMAP expected at the ErL50 is given below:
Analytically Measured Aqueous Phase (AMAP) calculated at the predicted ErL50.
constituents |
concentration in the WAF (mg.L-1) |
Constituent 1 |
8.30 |
Constituent 2 |
0.903 |
Constituent 3 |
0.108 |
Constituent 4 |
0.0945 |
Constituent 5 |
3.32E-05 |
Constituent 6 |
6.41E-06 |
Constituent 7 |
0.126 |
Constituent 8 |
5.31E-03 |
Constituent 9 |
0.185 |
Constituent 10 |
6.84E-04 |
Description of key information
The following toxicity value has been found for the registered substance:72h-ErL50 = 15 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 15 mg/L
Additional information
For that endpoint, one study with the registered substance was available. Indeed, the toxicity to aquatic algae of the registered substance has been investigated using an in-house calculation method that replaces an OECD 201 study and guideline for Testing of Chemicals No. 23 (i.e. WAF conditions).
A typical composition of the substance has been investigated.The algorithm used for the purpose of this study is based on a QSAR model which has been validated to be compliant with the OECD recommendations for QSAR modeling (OECD, 2004).
A calculation method was used to predict the inhibition of algal growth exposed to the test item OLIBANUM OIL (Bowsellia papyrifera), using the WAF method. This calculation method predicts the endpoint value which would be expected when testing the substance under experimental conditions in a laboratory following the Guideline for Testing of Chemicals No. 201, "Freshwater Alga and Cyanobacteria, Growth Inhibition Test", referenced as Method C.3 of Commission Regulation No. 440/2008 (2) adapted for testing of a mixture using the WAF method. The criterion measured was the median effective loading rate of the mixture ErL50 (Median Effective Loading for specific growth rate), a statistically derived loading rate which is expected to cause 50% inhibition of intrinsic rate of growth of the test system within a period of 72 hours.
The result below is the toxicity value anticipated during a 72-hour ErL50study on algae based on the composition of OLIBANUM OIL (Bowsellia papyrifera).
The 72-hour ErL50is calculated as follows:
The 72-hour ErL50is calculated as follows:
Composition |
Time (h) |
ErL50(mg test item.L-1) |
typical |
72 |
15 |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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