Registration Dossier
Registration Dossier
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EC number: 238-242-6 | CAS number: 14306-25-3
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in mammalian cells
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- CCRIS: PHYTIC ACID. CASRN: 83-86-3
- Author:
- CCRIS Record Number: 4513
- Year:
- 2 010
- Bibliographic source:
- CCRIS: PHYTIC ACID. CASRN: 83-86-3
Materials and methods
- GLP compliance:
- not specified
- Type of assay:
- in vitro mammalian cell gene mutation tests using the thymidine kinase gene
Test material
- Reference substance name:
- Fytic acid
- EC Number:
- 201-506-6
- EC Name:
- Fytic acid
- Cas Number:
- 83-86-3
- Molecular formula:
- C6H18O24P6
- IUPAC Name:
- cyclohexane-1,2,3,4,5,6-hexayl hexakis[dihydrogen (phosphate)]
- Test material form:
- not specified
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- mouse lymphoma L5178Y cells
- Details on mammalian cell type (if applicable):
- L5178Y (TK+/TK-)
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- RAT, LIVER, S-9, AROCLOR 1254
- Test concentrations with justification for top dose:
- 1000-5000 µg/plate
- Vehicle / solvent:
- Sterile distilled water
- Details on test system and experimental conditions:
- Suspension/plate method.
Results and discussion
Test results
- Key result
- Species / strain:
- mouse lymphoma L5178Y cells
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Based on the study results, the substance is not a mutagen.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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