Registration Dossier
Registration Dossier
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EC number: 238-242-6 | CAS number: 14306-25-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Substance Name: Sodium inositol hexaphosphate
- Author:
- ChemIDplus
- Bibliographic source:
- ChemIDplus - Substance Name: Sodium inositol hexaphosphate. RN: 14306-25-3
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Myo-Inositol, hexakis(dihydrogen phosphate), sodium salt
- EC Number:
- 238-242-6
- EC Name:
- Myo-Inositol, hexakis(dihydrogen phosphate), sodium salt
- Cas Number:
- 14306-25-3
- Molecular formula:
- C6H18O24P6.xNa
- IUPAC Name:
- sodium 2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl hydrogen phosphate
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- other: guinea pig, mouse, rabbit, rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: intraperitoneal, subcutaneous, intravenous
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LDLo
- Remarks:
- guinea pig - intraperitoneal route
- Effect level:
- 400 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- not specified
- Dose descriptor:
- LDLo
- Remarks:
- guinea pig - subcutaneous route
- Effect level:
- 4 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Remarks:
- mouse - intraperitoneal route
- Effect level:
- 83 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- not specified
- Dose descriptor:
- LDLo
- Remarks:
- rabbit - intravenous route
- Effect level:
- 23 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- not specified
- Dose descriptor:
- LDLo
- Remarks:
- rabbit - subcutaneous route
- Effect level:
- 1 400 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Remarks:
- rat - intraperitoneal route
- Effect level:
- 195 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Conclusions:
- Based on the data availble, the substance can be cause lethality by several injective administration routes which should be considered as worst case. Overall, the C&L of the substance for acute toxicity cannot be excluded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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