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EC number: 237-732-7 | CAS number: 13952-84-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
There are one acute oral toxicity study, one acute inhalation toxicity study and one acute dermal toxicity study.
1- The LD 50 values (mg/kg body wt) for oral toxicity were for male, 157.5 mg/kg and for female, 146.8 mg/kg.
2 -The LC 50 was set at 11.2 mg/l (3680 ppm).
3 -The LD 50 for acute dermal toxicity was: LD 50: 200-2000 mg/kg/day
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: public study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Principles of method if other than guideline:
- Male and female weanling Sprague-Dawley CD rats
of the same age were obtained from the Charles River
Breeding Laboratories, Wilmington, Massachusetts.
These animais were housed two per cage and were acclimated
to laboratory conditions for 2 weeks prior to
initiation of the experiment. Laboratory temperatures
ranged from 22 to 26°C, and the relative humidity
ranged from 22 to 49%. A 12-hr light-dark schedulewas maintained with the light cycle beginning at 7:00
AM. Except for an 18-hr period immediately prior to
treatment, the animais were provided with Rodent Laboratory
Chow (Ralston Purina Co., St. Louis, Mo.). Tap
water was available ad libitum.
In a range-finding study, rats were treated in groups
of two males and two females with various amounts of
the test compound. From the resulting mortality data,
a range of doses was
established. Solutions of the monobutylamines were
then prepared in corn oil such that doses of 1 OO, 200,
300, 400, 500, and 600 mg/kg body wt for sec.-butylamine,
could be administered in a constant 4-ml volume.
Upon initiation of the toxicity experiment, the rats
were starved overnight, weighed (males, 194. 7 ± 20. 5
g; females, 156 ± 16.8 g), and randomly assigned to 24
dosage groups, each group consisting of 10 male and 10
female rats. The specified doses of each monobutylamine
were administered, by gavage, to ail rats within the corresponding
dosage groups. These animais were observed
for signs of toxicity or mortality during the subsequent
14-day period, and those that died during this period
were subjected to gross pathological examination. LD,0
values for each monobutylamine were calculated for
both niales and females from the mortality in the several
groups by the probit method of Finney ( 1971 ). - GLP compliance:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- These animais were observed
for signs of toxicity or mortality during the subsequent
14-day period, and those that died during this period
were subjected to gross pathological examination. LD,0
values for each monobutylamine were calculated for
both niales and females from the mortality in the several
groups by the probit method of Finney ( 1971 ). - Doses:
- 1 OO, 200,300, 400, 500, and 600 mg/kg body wt for sec.-butylamine
- No. of animals per sex per dose:
- 2 males and 2 females
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 157.5 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 146.8 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 152.4 mg/kg bw
- Based on:
- test mat.
- Mortality:
- sedation, ataxia, nasal
discharge, gasping, salivation, and, at higher
doses, convulsions and death. At the dose
levels tested, death generally occurred within
1 to 3 hr after administration of the amine.
Animais which survived the 14-day period
appeared normal and were not further examined.
Gross pathological examination of
animais that died following treatment showed pulmonary edema - Clinical signs:
- other: sedation, ataxia, nasal discharge, gasping, salivation, and, at higher doses, convulsions and death. At the dose levels tested, death generally occurred within 1 to 3 hr after administration of the amine. Animais which survived the 14-day period appeared
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Sec butylamine is toxic after oral ingestion in rats.
- Executive summary:
The LD50 values for the substance was calculated by the probit method.
No significant sex-related differences were noted. The 14-day, po single-dose
LD50 values (mg/kg body wt) were: for male, 157.5 mg/kg, and for female, 146.8 mg/kg.
Reference
sec.-Butylamine LD (50) slope (+/_ SD)
M 157.5 ( 35.1 -242.8) 1.89 (±0.67)
F 146.8 (12.4-239.3) 1.67 (±0.66)
M and F 152.4 (69.3-214.8) 1.78 (±0.47)
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 157.5 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- mouse
- Strain:
- other: WBS/S
- Details on test animals or test system and environmental conditions:
- 5 MALES OF wbs/s MICE 527+/- g BW) were placed in each of a series of 20-liter exposure chambers and the latter sealed airtight. A measured volume of the sample was then injected upon a disc of filter paper suspended in each chamber. (The sample was seen to evaporate completely within 20 seconds). The mice were observed continuously during an exposure period of one hour and suviving animals were observed for 11 days.
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Details on inhalation exposure:
- 5 MALES OF wbs/s MICE 527+/- g BW) were placed in each of a series of 20-litter exposure chambers and the latter sealed airtight. A measured volume of the sample was then injected upon a disc of filter paper suspended in each chamber. (The sample was seen to evaporate completely within 20 seconds). The mice were observed continuously during an exposure period of one hour and suviving animals were observed for 11 days.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- 8, 10, 12.5, 16, 20 and 25 mg/l
- No. of animals per sex per dose:
- 5 males
- Control animals:
- no
- Details on study design:
- 5 MALES OF wbs/s MICE 527+/- g BW) were placed in each of a series of 20-litter exposure chambers and the latter sealed airtight. A measured volume of the sample was then injected upon a disc of filter paper suspended in each chamber. (The sample was seen to evaporate completely within 20 seconds). The mice were observed continuously during an exposure period of one hour and suviving animals were observed for 11 days.
- Statistics:
- none
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 11.2 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- 0 % mortality at 8 mg/L
20% mortality at 10 mg/l
80% mortality at 12.5 mg/L
100% mortality at 16 mg/L
100% mortality at 20 mg/l
100% mortality at 25 mg/l - Clinical signs:
- other: severe sensory irritation, dffrantic escape activity, salivation and bronchospastic gasping.
- Body weight:
- not recorded
- Gross pathology:
- not examined
- Interpretation of results:
- Category 3 based on GHS criteria
- Executive summary:
5 males of wbs/s MICE 527+/- g BW were placed in each of a series of 20-litter exposure chambers and the latter sealed airtight. A measured volume of the sample was then injected upon a disc of filter paper suspended in each chamber. (The sample was seen to evaporate completely within 20 seconds). The mice were observed continuously during an exposure period of one hour and suviving animals were observed for 11 days. The LC 50 was set at 11.2 mg/l (3680 ppm).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 11 200 mg/m³ air
- Quality of whole database:
- Old study comparable to guideline.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Type of coverage:
- occlusive
- Vehicle:
- other: 200 mg/kg (10% aqueous solution) and 2000 mg/kg pure
- Duration of exposure:
- 24hours
- Doses:
- 200 and 2000 mg/kg
- No. of animals per sex per dose:
- 6 males/rats
- Control animals:
- no
- Details on study design:
- Doses were applied to the hair-clipped skin of the trunk under an occluding sleeve on each animal. The sleeves were removed 24 hours later and survivors were observed for 7 days.
- Statistics:
- none
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 200 - <= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At 2000 mg/kg: contact with the undiluted sample caused pain. Erythema appeared immediately and then became black within 10 minutes. 2 of 3 rats dies overnight (>3 hours). Large areas of skin were completely destroyed in each of the animals.
- Clinical signs:
- other: not recorded.
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- LD 50: 200-2000 mg/kg/day
- Executive summary:
Three rats were treated dermally with 2000 mg/kg and three were treated with 200 mg/kg (10% aqueous solution). Doses were applied to the hair clipped skin of the trunk under an occluding sleeve on each animal.The sleeves were removed 24 hours later and survivors were observed for seven days.
2000 mg/kg : contact with the undiluted sample caused pain appeared immediately and then became black within ten minutes.Two of the three rats died overnight (>3hours). Large areas of skin were completely destroyed in each of the animals.
200 mg/kg: contact with 10% dilution also caused pain. Erythema appeared within one minute and persisted without further change. None of the rats died. Scattered scabs were formed on each animal.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 200 mg/kg bw
- Quality of whole database:
- Old study comparable to guideline
Additional information
Justification for classification or non-classification
Proposed classification according to Regulation EC 1272/2008
Oral route: cat 3; hazard label H 301
Inhalation: cat 3; hazard label H 331
Dermal: cat 3; Hazard label H311
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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