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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Justification for type of information:
Please refer to analogue justification provided in IUCLID section 13.
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
WAF
Basis for effect:
mortality (fish)
Remarks on result:
other: No further processing of the test solution
Remarks:
Source, RA-A, CAS 1338-39-2, 2012, Danio rerio 98h
Duration:
96 h
Dose descriptor:
LL50
Effect conc.:
> 10 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
WAF
Basis for effect:
mortality (fish)
Remarks on result:
other:
Remarks:
Source, RA-A, CAS 1338-41-6, 2005, O. latipes 96 h

Description of key information

LC50 (96 h) > 100 mg/L (OECD 203, read-across)

Key value for chemical safety assessment

Additional information

Experimental studies investigating acute toxic effects of the target substance Sorbitan tridocosanoate on fish are not available. Thus, in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally related source substances Sorbitan laurate (CAS 1338-39-2) and Sorbitan stearate (CAS No.1338-41-6) was conducted to fulfil the data requirements according to Annex VIII. The most suitable (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. The read-across approach is justified in detail within the analogue justification in IUCLID Section 13.

The study on the source substance Sorbitan laurate (CAS 1338-39-2) was performed as a limit test, according to OECD Guideline 203 and GLP. Fish (Danio rerio) were exposed to a nominal test concentration of 100 mg/L, prepared as water accommodated fraction (WAF). No mortalities were recorded during the 96-hour test period. The determined LC50 (96 h) is > 100 mg/L.

The available study on the source substance Sorbitan stearate (CAS 1338-41-6) was conducted as a limit test, according to the Circular on Test Methods of New Chemical Substances (Japan). A semi-static system was set up. The fish (Oryzias latipes) were exposed to a nominal test concentration of 1000 mg/L, prepared as water accommodated fraction (WAF). An analytical dose verification was performed using LC/MS measurements. The measured concentration was 13.7 mg/L (TWA), which is far above the determined water solubility of < 0.525 mg/L at 20 °C. Due to the fact that the substance is an UVCB and the preparation of a WAF it was considered to be more appropriate to use the nominal loading rate for the assessment. No mortalities were observed during the 96-hour test period. The recorded LL50 is > 1000 mg/L based on the nominal loading rate