L-cystine dihydrochloride

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-04-06

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

Deviations:

no

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.1 (Test method for readily combustible solids)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Key result

Test procedure:

burning rate test: preliminary screening test

Remarks on result:

substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period

Safety pre-test

The test item expanded, carbonized and burned with a lot of smoke and a yellow-orange flame.

Preliminary screening test

The test item expanded and carbonized. Smoke was observed.

Interpretation of results:

GHS criteria not met

Conclusions:

No ignition was observed throughout the course of the test. The test item should be considered as not highly flammable (for EU regulations) and non-flammable solid (for UN regulations), respectively.

Executive summary:

A preliminary test according to UN N.1 and Regulation (EC) No. 440/2008 method A.10 was performed in order to determine the flammability of the test substance (reference 4.13-1). In the preliminary screening test the test item was heated with the flame of a Teclu burner. The test item expanded and carbonized. Smoke was observed. No ignition and no signs of flammability were observed. Therefore the test item was considered as not highly flammable (for EU regulations) and non-flammable solid (for UN regulations).

Reference 2

Endpoint:

flammable gases

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because the substance is a solid

Reference 3

Endpoint:

pyrophoric solids

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is known to be stable in contact with air at room temperature for prolonged periods of time (days) and hence, the classification procedure does not need to be applied

Reference 4

Endpoint:

self-heating substances / mixtures

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Reference 5

Endpoint:

substances / mixtures which in contact with water emit flammable gases

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the experience in production or handling shows that the substance does not react with water, e.g. the substance is manufactured with water or washed with water

Reference 6

Endpoint:

pyrophoric liquids

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because the substance is a solid

Description of key information

The substance is not considered as flammable, flammable in contact with water, pyrophoric and self-heating.

Key value for chemical safety assessment

Flammability:

not classified

Additional information

Flammable solids (reference 4.13-1)

A preliminary test according to UN N.1 and Regulation (EC) No. 440/2008 method A.10 was performed in order to determine the flammability of the test substance (reference 4.13-1).In the preliminary screening test the test item was heated with the flame of a Teclu burner. The test item expanded and carbonized. Smoke was observed. No ignition and no signs of flammability were observed. Therefore the test item was considered as not highly flammable (for EU regulations) and non-flammable solid (for UN regulations).

Flammable liquids (reference 4.11-1)

In accordance with column 2 Annex VII section 7.9 of Regulation (EC) No. 1907/2006 (REACH), the test on flash point does not need to be conducted as the test substance is solid with a melting point > 200 °C.

Flammable gases (4.13-2)

The test item is a solid at ambient conditions. This hazard class is only applicable for gases. Thus, the substance was not considered for classification as flammable gas.

Pyrophoric properties of liquids (reference 4.13-3)

The test item is a solid at ambient conditions. This hazard class is only applicable for liquids. Thus, the substance was not considered for classification as pyrophoric liquid.

Pyrophoric properties of solids (reference 4.13-4)

In accordance with section 2.10.4.1, Annex I of Regulation (EC) No 1272/2008, the classification procedure for pyrophoric solids need not to be applied when experience in manufacture or handling shows that the substance or mixture does not ignite spontaneously on coming into contact with air at normal temperatures (i.e. the substance is known to be stable at room temperature for prolonged periods of time (days)).

Thus, no study was conducted and the substance was not considered for classification as pyrophoric solid.

Self-heating substances and mixtures (reference 4.13-5)

In accordance with section 2.11.4.2 of Regulation (EC) 1272/2008 the item was not considered to be a self-heating substance, because no self-ignition could be stated up to the melting point (211.36 °C) in the ZPA-3 oven (test performed according to test method A.16). Thus, no self-heating test was performed for the test item.

Substances which, in contact with water, emit flammable gases (4.13-6) 

In accordance with column 2 of REACH Annex VII and with Regulation (EC) No 1272/2008 Annex I, section 2.12.4.1(b) the classification procedure for this hazard class need not be applied. Based on the experience in handling and use the substance does not react with water and in addition the test substance is not pyrophoric. Thus, no study was conducted and the substance was not considered for classification.

Flammable Aerosols

In accordance with Annex I of Regulation (EC) No. 1272/2008, section 2.3 the classification procedure for this hazard class does not apply, since the test substance is not used as an aerosol. Thus, no study was conducted and the substance was not considered for classification.

Justification for classification or non-classification

In accordance with Annex I, Section 2.2, Section 2.3, Section 2.6, Section 2.7, Section 2.9, Section 2.10 Section 2.11 and Section 2.12 of Regulation (EC) No 1272/2008 the substance has not to be classified as readily combustible solid, self-heating substance, substance which emits flammable gases in contact with water, pyrophoric solid, pyrophoric liquid, flammable gas or as aerosol.