L-cystine dihydrochloride

Auto flammability

Link to relevant study record(s)

Reference

Endpoint:

relative self-ignition temperature (solids)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2017-06-12 to 2017-06-13

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.16 (Relative Self-Ignition Temperature for Solids)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Key result

Remarks on result:

no self-ignition observed up to the melting point

Temperature data

The temperatures which were measured in the experiment are presented in the following table. As many values were recorded, only the values of every 60 minutes (until the oven had reached the chosen temperature) are presented.

Table 2: Presentation of temperatures versus time

Time in min	Temperature (test item) in°C	Temperature (oven) in°C
5	21.4	20.8
60	35.4	47.3
120	65.8	82.6
180	98.5	118.0
240	131.6	154.2
300	167.1	190.6
340	184.4	212.7

After the test was finished, the test item had changed its colour to black, had expanded and carbonized.

Conclusions:

The test item was determined to be not auto-flammabile up to the melting point of 211.4 °C. No increase in the temperature of the sample in comparison to the oven could be detected. After the test was finished, the test item had changed its colour to black, had expanded and carbonized.

Executive summary:

A study was performed according to Regulation (EC) No. 440/2008 method A.16 in order to determine the relative self-ignition temperature of the test item with the help of an ZPA-3 oven. The test item was filled into a stainless steel cube and heated from room temperature up to an oven temperature of 213 °C (heating rate 0.5 K/min). No increase in the temperature of the sample in comparison to that of the oven could be detected and no signs of ignition were observed. The test item was considered as not self-igniting up to the melting point of 211.4 °C under the test conditions. After the test was finished, the test item had changed its colour to black, had expanded and carbonized.

Description of key information

The test item was determined to be not auto-flammable up to the melting point of 211.4 °C. No increase in the temperature of the sample in comparison to the oven could be detected. After the test was finished, the test item had changed its colour to black, had expanded and carbonized.

Additional information

A study was performed according to Regulation (EC) No. 440/2008 method A.16 in order to determine the relative self-ignition temperature of the test item with the help of an ZPA-3 oven. The test item was filled into a stainless steel cube and heated from room temperature up to an oven temperature of 213 °C (heating rate 0.5 K/min). No increase in the temperature of the sample in comparison to that of the oven could be detected and no signs of ignition were observed. The test item was considered as not self-igniting up to the melting point of 211.4 °C under the test conditions. After the test was finished, the test item had changed its colour to black, had expanded and carbonized (reference 4.12-1).