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EC number: 210-043-9 | CAS number: 603-48-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The potential for the test substance to produce acute toxicity after a single oral administration was determined.
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- N,N,N',N',N'',N''-hexamethyl-4,4',4''-methylidynetrianiline
- EC Number:
- 210-043-9
- EC Name:
- N,N,N',N',N'',N''-hexamethyl-4,4',4''-methylidynetrianiline
- Cas Number:
- 603-48-5
- Molecular formula:
- C25H31N3
- IUPAC Name:
- 4-{bis[4-(dimethylamino)phenyl]methyl}-N,N-dimethylaniline
- Test material form:
- solid
- Details on test material:
- - Purity: not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: DR. K. Thomae GMBH, D-7950 Biberach, FRG
- Females (if applicable) nulliparous and non-pregnant: not reported
- Age at study initiation: not reported
- Weight at study initiation: Males, 213 g and Females, 201 g
- Fasting period before study: The animals were given no feed about 16 hours before administration
- Housing: Stainless steel wire mesh cages, type DK-III (Becker & Co., Castrop-Rauxel, FRG)
- Diet: ad libitum, except for approximately 16 hours before administration
- Water: Tap water, ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature: 20-24°C
- Humidity: 30-70%
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12 hrs dark (18:00 to 06:00) and 12 hrs light (06:00 to 18:00)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5% Aqueous carboxymethyl cellulose
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25% (w/v)
- Amount of vehicle (if gavage): 15 mL/kg
- Justification for choice of vehicle: Aqueous formulation corresponds to the physiological medium
- Lot/batch no. (if required): R 243/181
- Purity: No data
MAXIMUM DOSE VOLUME APPLIED: 20 mL/kg - Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Recording of signs and symptoms several times on the day of administration. at least once each workday. Check for moribund and dead animals twice each workday and once on holidays. Animals were weighed at beginning of the test and at 7 and 13 days after dose administration.
- Necropsy of survivors performed: yes - Statistics:
- No
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred
- Clinical signs:
- other: No clinical signs were observed
- Gross pathology:
- No gross pathology was found
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 > 5000 mg/kg
- Executive summary:
Groups of 5 male and 5 female rats were administered by gavage, 5000 mg/kg of the test substance as a suspension in 0.5% aqueous carboxymethyl cellulose. The animals were checked for signs and symptoms several times on the day of administration, and at least once each workday. A check was made for moribund and dead animals twice each workday and once on holidays. After the 14-day observation period, the animals were sacrificed and then necropsy with gross-pathological examination.
No deaths occurred and there were no clinical signs of toxicity nor were any pathological changes seen at necropsy. The LD50 of the test substance is >5000 mg/kg.
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