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EC number: 210-043-9 | CAS number: 603-48-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- Preparation of the quality control samples were not prepared at concentrations below the measured water solubility.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- Preparation of the quality control samples were not prepared at concentrations below the measured water solubility.
- GLP compliance:
- yes
- Type of method:
- flask method
Test material
- Reference substance name:
- N,N,N',N',N'',N''-hexamethyl-4,4',4''-methylidynetrianiline
- EC Number:
- 210-043-9
- EC Name:
- N,N,N',N',N'',N''-hexamethyl-4,4',4''-methylidynetrianiline
- Cas Number:
- 603-48-5
- Molecular formula:
- C25H31N3
- IUPAC Name:
- 4-{bis[4-(dimethylamino)phenyl]methyl}-N,N-dimethylaniline
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Purity: 99.4%
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- 1.3 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- > 24 - < 72 h
- Temp.:
- 20 °C
- pH:
- >= 7.423 - <= 8.714
- Details on results:
- Preliminary Test: The preliminary test yielded an approximate solubility of <0.0992 mg/mL in water. Definitive Test: The solubility of the test substance was determined from the 48 and 72 hour timepoints to be 1.30 μg/mL (0.00130 g/L) with a CV of 19%. Samples were not in equilibrium at the 24 hour timepoint which was slightly higher in concentration than the 48 and 72 hour timepoints. Although variability was observed, the samples were in equilibrium as values did not significantly increase over time. The temperature for the chamber during the testing was within 20 ± 1°C. The pH for the 24, 48, and 72-hour test samples was measured as 7.932, 7.423, and 8.714, respectively. The quality control samples yielded recoveries that ranged from 80.7 to 94.1% of the nominal concentration of test substance and verified the analyses. A protocol deviation occurred during the preparation of the quality control samples in that they were not prepared at concentrations below the measured water solubility. Quality control samples were prepared below the estimated water solubility of the test material because the actual water solubility was unknown at the point the QC samples were prepared due to concurrent analysis with test samples. No effect on the study is anticipated because the low water solubility of the test material meant that the QCs were prepared using a spiking solvent. The test substance was soluble at the prepared levels in the presence of the spiking solvent as evidenced by an average recovery of 89.8%. Additionally, the limit of quantitation was determined to be 0.326 μg/mL after the test to ensure the definitive samples could be quantitated accurately at the level of solubility.
Applicant's summary and conclusion
- Conclusions:
- The solubility in water of the test substance was 1.3 mg/L at 20°C.
- Executive summary:
The solubility of the test substance in water was determined by producing a saturated solution over time using the shake flask method and analysing the solution for the test substance using a high performance liquid chromatography system with diode array detection (HPLC-DAD) in accordance with OECD Guideline 105.
The solubility in water of the test substance was 1.3 mg/L at 20°C.
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