Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 695-101-5 | CAS number: 1275611-65-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The potential for bioaccumulation is low.
Additional information
Bioaccumulation potential
Standard OECD 305 tests are technically very complicated with strongly sorbing ready biodegradable substances. In addition is the route of exposure in a standard OECD 305 test via the aquatic route unrealistic for these substances because the substance will either be sorbed or biodegraded. OECD 305-I, II and III testing is therefore considered not technically feasible and should be waived according to annex XI (section 2) of REACh regulation EC 1907/2006. No measured BCF fish is therefore available.
The log Kow value available has been calculated from the ratio of the octanol solubility and CMC. This value can be used as a worst-case log Kow and is considered acceptable. In the absence of measured BCF data, the BCF was calculated using the BCFBAF v3.0 estimation program as included in EPIweb v4.0. Based on a measured log Kow of 4.06 a BCF is calculated of 70.8 L/kg ww for the protonated N-C16-18-alkyl-(even numbered, C18 unsaturated) trimethylpropane-1,3-diamine and 9.36 L/kg for the non-protonated molecule.
The biodegradability is a strong indication that this substance is also metabolized in fish. In vitro biotransformation by rainbow trout hepatic subcellulair fraction has been observed for primary alkyl amines and alkyl propane-1,3-diamines. It is therefore likely that also for the methylated diamine biotransformation will be observed.
The calculated BCF indicates a low bioaccumulation potential. N-C16-18-alkyl-(even numbered, C18 unsaturated) trimethylpropane-1,3-diamine is almost completely protonated under ambient conditions. In addition, the bioavailable fraction of N-C16-18-alkyl-(even numbered, C18 unsaturated) trimethylpropane-1,3-diamine is quickly degraded and a chronic exposure to a significant concentration in the aquatic compartment is therefore unlikely (the substance is either sorbed or degraded).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.