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Diss Factsheets
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EC number: 204-977-6 | CAS number: 130-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Although conducted before the OECD Guideline 401 came into effect, the procedures used on this study were comparable in terms of species used, number of animals, dose selection and observations made.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,4-naphthoquinone
- EC Number:
- 204-977-6
- EC Name:
- 1,4-naphthoquinone
- Cas Number:
- 130-15-4
- Molecular formula:
- C10H6O2
- IUPAC Name:
- 1,4-naphthoquinone
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Shizuoka Laboratory Animal Agriculture Co-operative association.
- Females (if applicable) nulliparous and non-pregnant: Yes
- Age at study initiation: Around 9 weeks
- Weight at study initiation: Males (260 to 300 g) and females (170 to 205 g).
- Fasting period before study: Witheld overnight prior to dosing
- Housing: No details
- Diet (e.g. ad libitum): Pelleted diet provided freely
- Water (e.g. ad libitum): tap water provided freely
- Acclimation period: At least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 to 25°C
- Humidity (%): 50 to 60%
- Air changes (per hr): Not detailed
- Photoperiod (hrs dark / hrs light): Not detailed
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5% (w/v) gum tragacanth water solution
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: Varies depending on dosage
- Amount of vehicle (if gavage): 5 mL/kg
- Doses:
- 130, 169 and 220 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females per sex per group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Bodweight was measured on the day of exposure and Days 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, and gross necropsy. - Statistics:
- LD50 calculated using Litchfield-Wilcoxon analysis
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 124 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 100% of animals that received 220 mg/kg were found dead by 1 day after dosing.
90% of animals that received 169 mg/kg were found dead by 1 day after dosing.
60% of animals that received 130 mg/kg were found dead by 1 day after dosing. - Clinical signs:
- other: Staggered gait was observed 5 minutes after treatment with lethargy and lack of spontaneous movement observed by 10 minutes in all dose groups. These findings were observed until 1 hour after treatment. Around half of the animals that received 169 or 220
- Gross pathology:
- Congestion and erosion was observed at the fundus of the stomach in animals which died shortly after treatment.Oedema was observed in animals which died up to 4 hours after treatment. Thickening and hardening of the cardia of the stomach was noted in all surviving animals on Day 14. In addition adhesion of the cardia of the stomach, liver and spleen was noted in one animal in each group receiving 130 or 169 mg/kg.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- A reliable near guideline study is available which provides a LD50 value of 124 mg/kg bw after a single dose of the substance. The test substance was considered to be highly stimulative to the stomach and induced acute gastritis which was regarded as the cause of death alongside CNS depression. Some evidence of recovery was noted in animals that survived until the end of the observation period.
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