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EC number: 209-667-4 | CAS number: 589-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
Toxicity to reproduction
The reproductive toxicity study of Octan-3-ol (589-98-0) was estimated by SSS (2018) using OECD QSAR toolbox v3.3 with log kow as the primary descriptor and NOAEL was estimated to be 880.33mg/kg bw. When male and female Sprague-Dawley rats were exposed with Octan-3-ol (589-98-0)orally.
Thus, based on based on the above predictions for target Octan-3-ol (589-98-0) and experimental study of it’s read across 2-Ethyl-1-Hexanol(104-76-7) and 2-Ethyl-1,3-hexanediol (94-96-2)cannot be classified as reproductive toxicant as per the CLP criteria of classification.
Link to relevant study records
- Endpoint:
- toxicity to reproduction
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is from OECD QSAR toolbox v3.3 and the QMRF report has been attached
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Prediction was done using OECD QSAR toolbox v3.3, 2018
- GLP compliance:
- not specified
- Limit test:
- no
- Justification for study design:
- No data available
- Specific details on test material used for the study:
- - Name of test material: 3-Octanol
- IUPAC name: Octan-3-ol
- Molecular formula: C8H18O
- Molecular weight: 130.229 g/mole
- Smiles : C([C@@H](CC)O)CCCC
- Inchl: 1S/C8H18O/c1-3-5-6-7-8(9)4-2/h8-9H,3-7H2,1-2H3
- Substance type: Organic
- Physical state: Colorless Liquid - Species:
- rat
- Strain:
- Sprague-Dawley
- Details on species / strain selection:
- No data available
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data available
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on exposure:
- No data available
- Details on mating procedure:
- No data available
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 12-13 weeks
- Frequency of treatment:
- Daily
- Details on study schedule:
- No data available
- Dose / conc.:
- 880.33 mg/kg bw/day (nominal)
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Positive control:
- No data available
- Parental animals: Observations and examinations:
- No data available
- Oestrous cyclicity (parental animals):
- No data available
- Sperm parameters (parental animals):
- No data available
- Litter observations:
- No data available
- Postmortem examinations (parental animals):
- No data available
- Postmortem examinations (offspring):
- No data available
- Statistics:
- No data available
- Reproductive indices:
- No data available
- Offspring viability indices:
- No data available
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
- Reproductive function: oestrous cycle:
- not specified
- Reproductive function: sperm measures:
- not examined
- Reproductive performance:
- no effects observed
- Dose descriptor:
- NOAEL
- Effect level:
- 880.33 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- reproductive performance
- Remarks on result:
- other: overall no effects on reproductive performance
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Treatment related:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality / viability:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Sexual maturation:
- not specified
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- not specified
- Histopathological findings:
- not specified
- Other effects:
- not specified
- Behaviour (functional findings):
- not specified
- Developmental immunotoxicity:
- not specified
- Dose descriptor:
- other: not specified
- Generation:
- other: not specified
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: not specified
- Remarks on result:
- not measured/tested
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Treatment related:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
- Reproductive effects observed:
- not specified
- Treatment related:
- not specified
- Relation to other toxic effects:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
- Conclusions:
- In reproductive toxicity study, NOAEL was estimated to be 880.33mg/kg bw. When male and female Sprague-Dawley rats were exposed with Octan-3-ol (589-98-0) orally.
- Executive summary:
The reproductive toxicity study of Octan-3-ol (589-98-0) was estimated by SSS (2018) using OECD QSAR toolbox v3.3 with log kow as the primary descriptor and NOAEL was estimated to be 880.33mg/kg bw. When male and female Sprague-Dawley rats were exposed with Octan-3-ol (589-98-0)orally.
.
Reference
The
prediction was based on dataset comprised from the following
descriptors: NOAEL
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((((((((((((("a"
or "b" or "c" or "d" )
and ("e"
and (
not "f")
)
)
and ("g"
and (
not "h")
)
)
and ("i"
and (
not "j")
)
)
and ("k"
and (
not "l")
)
)
and ("m"
and (
not "n")
)
)
and "o" )
and ("p"
and (
not "q")
)
)
and ("r"
and (
not "s")
)
)
and ("t"
and (
not "u")
)
)
and "v" )
and "w" )
and "x" )
and ("y"
and (
not "z")
)
)
and ("aa"
and "ab" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Alcohol AND Hydroxy compound AND
Secondary alcohol by Organic functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] AND
Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Hydroxy,
aliphatic attach [-OH] by Organic functional groups (US EPA)
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Alcohol by Organic Functional
groups (nested)
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Alcohol by Organic Functional
groups
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OECD
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Michael addition OR Michael
addition >> P450 Mediated Activation to Quinones and Quinone-type
Chemicals OR Michael addition >> P450 Mediated Activation to Quinones
and Quinone-type Chemicals >> Arenes OR Schiff base formers OR Schiff
base formers >> Chemicals Activated by P450 to Glyoxal OR Schiff base
formers >> Chemicals Activated by P450 to Glyoxal >> Ethanolamines
(including morpholine) OR Schiff base formers >> Chemicals Activated by
P450 to Glyoxal >> Ethylenediamines (including piperazine) OR SN1 OR
SN1 >> Iminium Ion Formation OR SN1 >> Iminium Ion Formation >>
Aliphatic tertiary amines OR SN1 >> Nitrenium Ion formation OR SN1 >>
Nitrenium Ion formation >> Tertiary aromatic amine by DNA binding by OECD
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Non binder, non cyclic structure
by Estrogen Receptor Binding
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Non binder, impaired OH or NH2
group OR Non binder, MW>500 OR Non binder, without OH or NH2 group OR
Very strong binder, OH group by Estrogen Receptor Binding
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as No alert found by Protein
binding by OASIS v1.3
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Acylation OR Acylation >> Ester
aminolysis OR Acylation >> Ester aminolysis >> Amides by Protein binding
by OASIS v1.3
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Not known precedent reproductive
and developmental toxic potential by DART scheme v.1.0
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Alkoxy propanol derivatives OR
Alkyl amide, urea, thiourea, nitroso urea, carbonate, guanidine and
carbamate derivatives (21b1) OR Alkyl amide, urea, thiourea, nitroso
urea, carbonate, guanidine and carbamate derivatives (21b1) >>
Alkylamide or thioamide analogs OR C1 to C4 non-branched alkyl alcohols-
sub category (25a) OR Di-substituted hydrocarbons (24a) OR Known
precedent reproductive and developmental toxic potential OR
Multi-halogenated alkyl ethers (23b) by DART scheme v.1.0
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as Not categorized by Repeated dose
(HESS)
Domain
logical expression index: "n"
Referential
boundary: The
target chemical should be classified as Thiocarbamates/Sulfides
(Hepatotoxicity) No rank by Repeated dose (HESS)
Domain
logical expression index: "o"
Referential
boundary: The
target chemical should be classified as Bioavailable by Lipinski Rule
Oasis ONLY
Domain
logical expression index: "p"
Referential
boundary: The
target chemical should be classified as Alcohol by Organic Functional
groups (nested)
Domain
logical expression index: "q"
Referential
boundary: The
target chemical should be classified as Aliphatic Amine, primary by
Organic Functional groups (nested)
Domain
logical expression index: "r"
Referential
boundary: The
target chemical should be classified as Non-Metals by Groups of elements
Domain
logical expression index: "s"
Referential
boundary: The
target chemical should be classified as Halogens by Groups of elements
Domain
logical expression index: "t"
Referential
boundary: The
target chemical should be classified as Inclusion rules not met by Skin
irritation/corrosion Inclusion rules by BfR
Domain
logical expression index: "u"
Referential
boundary: The
target chemical should be classified as Ketones by Skin
irritation/corrosion Inclusion rules by BfR
Domain
logical expression index: "v"
Similarity
boundary:Target:
CCCCCC(O)CC
Threshold=80%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain
logical expression index: "w"
Similarity
boundary:Target:
CCCCCC(O)CC
Threshold=10%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain
logical expression index: "x"
Similarity
boundary:Target:
CCCCCC(O)CC
Threshold=40%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain
logical expression index: "y"
Referential
boundary: The
target chemical should be classified as Alcohol AND Hydroxy compound AND
Secondary alcohol by Organic functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "z"
Referential
boundary: The
target chemical should be classified as Tertiary alcohol by Organic
functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "aa"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 0.277
Domain
logical expression index: "ab"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 3.56
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 880.33 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- Data is Klimicsh 2 and from QSAR Toolbox 3.3. (2018)
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Reproductive toxicity
In different studies on Octan-3-ol (589-98-0) has been investigated for reproductive toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rats for Octan-3-ol (589-98-0).The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies performed on structurally similar read across substance.
The reproductive toxicity study of Octan-3-ol (589-98-0) was estimated by SSS (2018) using OECD QSAR toolbox v3.3 with log kow as the primary descriptor and NOAEL was estimated to be 880.33mg/kg bw. When male and female Sprague-Dawley rats were exposed with Octan-3-ol (589-98-0)orally.
It is supported by experimental study conducted by R . W . TYL, L. C. FISHER et.al (Fundamental and Applied Toxicology 19, 176-185 (1992)) on structurally similar read across substance treated with 2-Ethyl-1-Hexanol(104-76-7).The reproductive and developmental toxicity study of 2-Ethyl-1-Hexanol(104-76-7) was performed on male and female Fischer 344 rats. 25 females /sex /dose group were used. The test material in dose concentration 0.0, 0.3, 1.0, and 3.0 ml/ kg/day (equivalent to 0,252,840, and 2520 mg/kg/day). Controls (0.0 ml/kg/day, sham controls) received deionized water at 3.0 ml/kg/day from gestation day 6 to 15.The test material in undiluted form applied in appropriate volume was dispensed from a 1.0-cc syringe on to the clipped and shaved dorsal skin (ca. I .5 in.) Between the scapulae, under a 2-in. gauze square. The application site was occluded with a Lycra-Spandex jacket with Velcro closures. A 1 .5 X 2.5-in. polyethylene patch was attached at the application site under the jacket. After a 6-hr exposure period the gauze and jacket were removed, and the application site was wiped gently with moist gauze and blotted dry.
Body weights were recorded on gds 0,6. 9, 12, 15. and 2 1. Food consumption was measured for each 3-day interval from gds 0 through 2 I. Observations were made at least once daily for clinical signs and skin irritation. Females which delivered early were terminated, examined grossly, and removed from the study. Surviving females in both studies were euthanized by CO2 asphyxiation on Day2 1. Maternal uterine and liver weights (both studies) and spleen, adrenals, kidneys, and thymus weights (main study) were recorded. Corpora lutea and uterine implantation sites were counted, and ovaries, cervices, vaginas, and abdominal and thoracic cavities were examined grossly. Uteri were examined externally, removed, and dissected longitudinally to expose the contents.All live and dead fetuses and resorption sites were noted; uteri from non-gravid females were tested for early resorptions with ammonium sulfide solution. All live fetuses were sexed, weighed, and examined for external malformations and for variations. After external examination approximately 50% of the live fetuses per litter from the main study were examined for visceral and craniofacial abnormalities .The remainder were examined for skeletal malformations and variations after evisceration, fixation in ethanol, and staining with alizarin red S
No females died, aborted, or were removed from either study in any control or treated group. Gestational weight changes (gds 0 through 2 1) were not significantly different from sham controls. Weight gain was significantly reduced for gds 6 through 9 at 2520 mg/kg/day compared with the sham control There were no significant changes in food consumption at any treatment level of study throughout gestation. Treatment-related effects attributable to test material at the application site were exfoliation, encrustation,and erythema. There was no edema. Erythema occurred during treatment with test material at levels of 840 mg/kg/day and above. Draize scores for irritation were essentially mild. Maximum mean treatment scores occurred on gd 14 at 168mg/kg/day(0.3, main study). The test material was without adverse effect at any treatment level i.e. 252, 840, 2520 mg/kg bwcompared with controls, on total and nonviable implants, early or late resorptions, live or dead fetuses, fetal sex ratio, and mean fetal body weights per litter There were no differences from controls for any treatment level i.e. 252, 840, 2520 mg/kg bwin maternal body weights, gravid uterine or corrected body weights, or in relative or absolute liver, thymus, spleen, adrenal and kidney weights. There were no differences from controls for any treatment level i.e. 252, 840, 2520 mg/kg bwin maternal body weights, gravid uterine or corrected body weights, or in relative or absolute liver, thymus, spleen, adrenal and kidney weights. There were no external, visceral, or skeletal malformations associated with any treatment level i.e. 252, 840, 2520 mg/kg bw of test material. Hencetheno observed adverse effect level (NOALE) was considered to be 840 mg/kgbw for reproductive toxicity and no observed adverse effect level (NOALE) was considered to be 2520 mg/kg bw for developmental toxicity as no toxic effects observed at highest dose tested. When female rats were treated with 2-Ethyl-1-Hexanol(104-76-7) by dermal application.
It is supported by experimental study conducted by Teresa L. Neeper-Bradley, Louan C. Fisher, Bonnie L. Butler, (j. toxicol. -cut. & ocular toxicol., 13(3), 203-214 (1994))on structurally similar read across substance treated with 2-Ethyl-1,3-hexanediol (94-96-2). The reproductive and developmental toxicity study of 2-Ethyl-1,3-hexanediol (94-96-2) was performed on CD female rats. The test material in dose concentration0,1 .0, 2.0, and 4.0 ml/kg/day(942,1884,3768mg/kg bw/day) or water was delivered directly by syringe to a 1.5x1.5 inch area of clipped dorsal trunk skin and was covered with a 2x2 inch sterilized gauze square and over this a2.75x2.75 inch square of polyvinyl film. A Lycra-Spandex jacket with Velcro closure was used to cover the dosing site. Aftera6 hr contact, the jacket and gauze were gently removed and the site washed with warm-water-dampened gauze. The scheduled sacrifice time was 6 days after the last treatment. The treatment with test material in undiluted form was given daily for 6 hr/day under occluded conditions over gd 6-15 inclusive. Rats were mated, one male to one female, in stainless steel cages, Females were inspected twice daily for vaginaloir(dropped copulation plugs. The presence of a dropped copulation plug was considered evidence of successful mating, and designated as gestation day (gd) 0. Twenty-five plug-positive females were assigned to each treatment group by a computer-randomized procedure according to body weight on gd 0.Animals were examined daily, twice during the treatment period, for clinical signs of toxic and/or pharmacologic effects and local skin irritation. Body weights were measured on gd 0, 6, 9, 12, 15, 18, and 21. Food consumption was measured over 3 day intervals from gd 0 to 21.
Surviving females were sacrificed on gd 21 by CQ, asphyxiation. Following thoracolaparotomy, the gravid uterus, ovaries, and other pelvic and abdominal viscera were inspected for signs of gross pathology. Ovarian corpora lutea were counted. Maternal and gravid uterine weights were measured. Uteri were dissected longitudinally, and live and dead fetuses and resorption sites counted. Uteri from non-pregnant animals were placed in 10% ammonium sulfide to detect early resorptions. All live fetuses were weighed, gender determined, and examined for external malformations and variations. Fetuses were anesthetized by hypothermia, and one-half of each litter was examined for thoracoabdominal visceral abnormalities. These fetuses were decapitated and the heads fixed in Bouin’s fluid for subsequent examination of craniofacial abnormalities using sectioning methods. The remaining fetuses in each litter were eviscerated, fixed in ethanol, processed for staining with alizarin redSand examined for skeletal malformations and variations. At necropsy there was no treatment-related gross pathology changes were observed. Fetal body weights were slightly reduced in the 3768mg/kg bw dose group, although not with statistical significance
No erythema or edema was seen at the dosing site. Exfoliation and crusting, possibly related to drying, were seen in a few animals of the 1884 and 3468 mg/kg/day groups. Although not statistically significant, maternal body weight gains were lower than for the controls for the 3768mg/kg /day -dose group over the whole treatment period, particularly during the first 3days of treatment . There were no significant or dose-related trends for changes in food consumption. There were no treatment-related effects on the average number of corpora lutea or implantations (total, viable, and nonviable); pre- and postimplantation losses were equivalent across all groups. There were no treatment-related differences from controls in terminal body weight or gravid uterine weight. statistically significant increases in absolute liver weight(1 1.6%)at3768mg/kg/ day dose group, and liver weight relative to corrected body weight was increased at all dosages, with mean increases of15.5%with3768mg/kg/day dose group, 7.8% for 1884 mg/kg/day, and 7.8% for942mg/kg/day. No significant difference in the incidence of external malformations or variations was observed,but a statistically significant increase in the incidence of unilateral hydroureter, compared with the concurrent control, was present at3768mg/kg/ day dose group, Therewas no apparent predominance associated with the side affected. Three visceral variations were statistically significantly increased at3768mg/kg/ day dose group, fetal atelectasis or partial fetal atelectasis, bilateral dilated lateral cerebral ventricle, and bilateral dilated ureters were also significantly increased at 1884 mg/kg/day.Although statistically there was an increase in the incidence of total skeletal malformations .this was considered not biologically significant because of an absence of a dose-response relationship. Hence theno observed adverse effect level (NOALE) was considered to be 942mg/kg bw/day(1.0ml/kg/day) for reproductive toxicity .When female rats were treated with 2-Ethyl-1,3-hexanediol (94-96-2)by dermal application during gestation.
Thus, based on based on the above predictions for target Octan-3-ol (589-98-0) and experimental study of it’s read across 2-Ethyl-1-Hexanol(104-76-7) and 2-Ethyl-1,3-hexanediol (94-96-2)cannot be classified as reproductive toxicant as per the CLP criteria of classification.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Thus, based on based on the above predictions for target Octan-3-ol (589-98-0) and experimental study of it’s read across 2-Ethyl-1-Hexanol(104-76-7) and 2-Ethyl-1,3-hexanediol (94-96-2)cannot be classified as reproductive toxicant as per the CLP criteria of classification.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.